Beta-sitosterol and its antinociceptive mechanism action

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dc.authorid0000-0002-9354-0000
dc.contributor.authorŞakul, Ayşe Arzu
dc.contributor.authorOkur, Mehmet Evren
dc.date.accessioned2022-06-24T10:59:53Z
dc.date.available2022-06-24T10:59:53Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractObjective: In this study, the possible central antinociceptive activity of beta-sitosterol is investigated along with its association of stimulation of opioidergic, serotonergic, adrenergic, and cholinergic receptors to mice central analgesia because of the beta-sitosterol administration. Material and Method: The beta-sitosterol was administrated to mice in various doses, such as 5, 10 and 20 mg/kg. Then, the mice analyzed via hot-plate and tail-flick assay to investigate the possible antinociceptive effects of beta-sitosterol. Additionally, in order to associate the mechanism of action mechanism, 20 mg/kg of beta-sitosterol was intraperitoneally administered to the animal which were previously pre-treated with opioid antagonist naloxone (5 mg/kg), serotonin 5-HT2A/2C receptor antagonist ketanserin (1 mg/kg), serotonin 5-HT3 receptor antagonist – ondansetron (1 mg/kg), ?2-adrenoceptor antagonist yohimbine (1 mg/kg) and muscarinic antagonist atropine (5 mg/kg), as well as nicotinic antagonist mecamylamine (1 mg/kg). Result and Discussion: The antinociceptive effect of beta-sitosterol was confirmed as dose-dependent for 5, 10, and 20 mg/kg doses in tail-flick and hot-plate tests. It can be concluded that beta-sitosterol promotes central antinociception effects associated with the spinal and supraspinal mediated cholinergic and opioidergic modulation.
dc.identifier.citationŞakul, A. A. ve Okur, M. E. (2022). Beta-sitosterol and its antinociceptive mechanism action. Journal of Faculty of Pharmacy of Ankara University, 46(2), 238-252. http://doi.org/10.33483/jfpau.882831q
dc.identifier.doi10.33483/jfpau.882831q
dc.identifier.endpage252
dc.identifier.issn1015-3918
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85131801768
dc.identifier.scopusqualityQ3
dc.identifier.startpage238
dc.identifier.urihttp://doi.org/10.33483/jfpau.882831q
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9540
dc.identifier.volume46
dc.indekslendigikaynakScopus
dc.institutionauthorŞakul, Ayşe Arzu
dc.language.isoen
dc.publisherAnkara University
dc.relation.ispartofJournal of Faculty of Pharmacy of Ankara Universityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntinociception
dc.subjectBeta-Sitosterol
dc.subjectCholinergic Receptors
dc.subjectOpioidergic Receptors
dc.titleBeta-sitosterol and its antinociceptive mechanism action
dc.title.alternativeBeta-sitosterol ve antinosiseptif etki mekanizması
dc.typeArticle

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