The impact of COVID-19 on patients with chronic obstructive pulmonary disease

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dc.authorid0000-0002-7902-5803
dc.authorid0000-0002-1502-1600
dc.authorid0000-0003-3540-6492
dc.authorid0000-0003-2862-3122
dc.contributor.authorBener, Abdulbari
dc.contributor.authorKök, Kıvanç
dc.contributor.authorNaser, Abdulrahman
dc.contributor.authorBarışık, Cem Cahit
dc.contributor.authorNurkalem, Zekeriya
dc.date.accessioned2023-07-10T07:40:37Z
dc.date.available2023-07-10T07:40:37Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıp Bilişimi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBACKGROUND: The aim of this study was to evaluate the risk of serious adverse outcomes in patients with chronic obstructive pulmonary disease (COPD) related to COVID-19 by stratifying the comorbidity status.METHODS: This is a prospective cohort study based on 1264 male and female patients, which were 25-75 years old. Nine hundred five (71.5%) patients gave consent to participate. The collected data included demographics, clinical, bio-chemistry, microbiology information, and the presence of disease. We performed descriptive and multivariate regression analyses to analyze the COVID-19 disease in the context of COPD.RESULTS: There was a significant difference between COPD versus control subjects with respect to age groups, BMI, smoking cigarette, comorbidity, infection, hypertension, stroke, coronary heart failure (CHF), diabetic and cerebral (P<0.001). The highly statistically significant differences were observed between COPD versus control subjects regard-ing, hemoglobin (P=0.022), HbA1C (P<0.001), glucose (P=0.040), vitamin D (P<0.001), vitamin B12 (P=0.020), triglyc-eride, uric acid (P<0.001), ferritin (P=0.002), Fe (P=0.004), and TSH (P=0.008), creatine-kinase (CK) (P=0.004), white blood cell (WBC) (P<0.001), hematocrit (P<0.001), monocytes (P<0.001), neutrophil (P<0.001), lymphocyte (P<0.001), platelet (P<0.001), aspartate transaminase-AST (P=0.018), alanine transaminase-ALT (P=0.008), respectively. The mul-tivariate stepwise regression analysis indicated that monocyte (P<0.001), hematocrit (P<0.001), lymphocyte (P<0.001), smoking (yes) (P<0.001), vitamin D (P<0.001), uric acid (P<0.001), diastolic BP (P<0.001), ferritin (P=0.002), infection (yes) (P=0.002), creatine kinase (P=0.006), metabolic syndrome (IDF) (P=0.008) and BMI kg/m2 (P=0.009) can be con-sidered as risk predictors of the COPD among COVID-19 patients after adjusting for age and gender.CONCLUSIONS: This study determined that COPD disease was the most prevalent comorbidity with CHF, hypertension and diabetes disease among COVID-19 patients. Interestingly, the current study revealed that 22.8% of COPD patients stated being smokers. The current study supports the evidence that COPD patients have worse outcomes from COVID-19 and explored the multiple factors responsible.(Cite this article as: Bener A, Kok K, Naser A, Barisik CC, Nurkalem Z. The impact of COVID-19 on patients with chronic obstructive pulmonary disease. Minerva Respir Med 2023;62:69-75. DOI: 10.23736/S2784-8477.22.02009-5)
dc.description.sponsorshipIstanbul Medipol University :10840098-604.01.01-E.14180en_US
dc.identifier.citationBener, A., Kök, K., Naser, A., Barışık, C. C. ve Nurkalem, Z. (2023). The impact of COVID-19 on patients with chronic obstructive pulmonary disease. Minerva Respiratory Medicine, 62(2), 69-75. https://dx.doi.org/10.23736/S2784-8477.22.02009-5
dc.identifier.doi10.23736/S2784-8477.22.02009-5
dc.identifier.endpage75
dc.identifier.issn2784-8477
dc.identifier.issn2724-6493
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85164770284
dc.identifier.scopusqualityN/A
dc.identifier.startpage69
dc.identifier.urihttps://dx.doi.org/10.23736/S2784-8477.22.02009-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11172
dc.identifier.volume62
dc.identifier.wos001010111900002en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBener, Abdulbari
dc.institutionauthorKök, Kıvanç
dc.institutionauthorBarışık, Cem Cahit
dc.institutionauthorNurkalem, Zekeriya
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofMinerva Respiratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEpidemiology
dc.subjectCOVID-19
dc.subjectComorbidity
dc.subjectHypertension
dc.titleThe impact of COVID-19 on patients with chronic obstructive pulmonary disease
dc.typeArticle

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