The effect of low-level laser therapy on the oxidative stress level and quality of life in patients with Hashimoto’s thyroiditis

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dc.authorid0000-0002-0101-2738
dc.authorid0000-0003-1985-552X
dc.authorid0000-0003-4075-4686
dc.authorid0000-0002-8662-5284
dc.authorid0000-0002-0675-1839
dc.contributor.authorTunç, Sümeyye
dc.contributor.authorAltuntaş, Şükriye Leyla
dc.contributor.authorAtmaca, Murat
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorLiou, Yeong Cheng
dc.contributor.authorChang, Wei An
dc.date.accessioned2024-06-06T11:11:51Z
dc.date.available2024-06-06T11:11:51Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Fizyoterapi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractThis study aimed to examine the effects of low-level laser therapy (LLLT) combined with levothyroxine replacement therapy on thyroid function, oxidative stress (OS), and quality of life in patients with Hashimoto’s thyroiditis (HT). Forty-six patients diagnosed with HT were randomized to receive active LLLT (n = 23) and sham LLLT (n = 23) twice a week for three weeks. Clinical and laboratory evaluations of the participants were performed before treatment and three months after treatment. Biochemical parameters were taken from the patient file requested by the physician as a routine examination. Malondialdehyde and nitricoxide indicating oxidant stress and superoxide dismutase, catalase, and glutathione, which indicate antioxidant capacity, were used in OS evaluation. The Oxidative Stress Index was calculated by measuring the Total Antioxidant Status and the Total Oxidant Status. At the end of our study, a significant improvement in oxidant and antioxidant biomarker levels showing OS and quality of life was observed in the treatment groups (p < 0.05). There was no change in thyroid function and autoimmunity at the end of the treatment between the two groups (p > 0.05). Improvements in glutathione levels and quality of life were significantly higher in the active treatment group than in the sham-controlled group. LLLT was found to be more effective on OS and quality of life in patients with HT than in patients in the sham-controlled group. It was concluded that LLLT is a safe and effective method that can be used in the treatment of patients with HT.
dc.identifier.citationTunç, S., Altuntaş, Ş. L., Atmaca, M., Çakıcı, Ç., Yiğitbaşı, T., Liou, Y. C. ... Chang, W. A. (2024). The effect of low-level laser therapy on the oxidative stress level and quality of life in patients with Hashimoto’s thyroiditis. Free Radical Research, 58(4), 249-260. http://dx.doi.org/10.1080/10715762.2024.2339892
dc.identifier.doi10.1080/10715762.2024.2339892
dc.identifier.endpage260
dc.identifier.issn1071-5762
dc.identifier.issn1029-2470
dc.identifier.issue4
dc.identifier.pmid38628043
dc.identifier.scopus2-s2.0-85190976828
dc.identifier.scopusqualityQ2
dc.identifier.startpage249
dc.identifier.urihttp://dx.doi.org/10.1080/10715762.2024.2339892
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12583
dc.identifier.volume58
dc.identifier.wos001204600800001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTunç, Sümeyye
dc.institutionauthorAltuntaş, Şükriye Leyla
dc.institutionauthorAtmaca, Murat
dc.institutionauthorÇakıcı, Çağrı
dc.institutionauthorYiğitbaşı, Türkan
dc.language.isoen
dc.relation.ispartofFree Radical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutoimmunity
dc.subjectHashimoto Thyroiditis
dc.subjectLow-Level Laser Therapy
dc.subjectOxidative Stress
dc.subjectQuality Of Life
dc.titleThe effect of low-level laser therapy on the oxidative stress level and quality of life in patients with Hashimoto’s thyroiditis
dc.typeArticle

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