Isolated extramedullary cutaneous relapse despite concomitant severe graft-vs.-host disease and tissue chimerism analysis in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: A case report

Basit Öğe Kaydı
dc.authorid0000-0003-3060-721X
dc.authorid0000-0003-1237-8281
dc.authorid0000-0003-0128-6947
dc.authorid0000-0002-6018-8936
dc.contributor.authorKantarcıoğlu, Bülent
dc.contributor.authorBeköz, Hüseyin Saffet
dc.contributor.authorDuvarcı Öğret, Yeliz
dc.contributor.authorÇakır, Aslı
dc.contributor.authorKıvanç, Demet
dc.contributor.authorOğuz Savran, Fatma
dc.contributor.authorSargın, Deniz
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:48Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:48Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000453169800014
dc.descriptionPubMed ID: 28105353
dc.description.abstractAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment option for patients with acute lymphoblastic leukemia (ALL). The curative potential of allo-HSCT for ALL is, in part, due to the graft-vs.-leukemia (GVL) effect, in addition to the intensive conditioning chemo-radiotherapy. However, relapse remains the major cause of treatment failure following allo-HSCT for ALL. In the allo-HSCT setting, testing for genetic markers of hematopoietic chimerism has become a part of the routine diagnostic program. Routine chimerism analysis is usually performed in peripheral blood or bone marrow; in fact, little is known about the value of tissue chimerism in patients with extramedullary relapse (EMR) after the allo-HSCT setting. The present study reports on, a case of a patient with ALL who experienced isolated cutaneous EMR despite ongoing graft-vs.-host disease (GVHD), and the results of peripheral blood and skin tissue chimerism studies using multiplex polymerase chain reaction (PCR) of short tandem repeats (STR-PCR). The present case demonstrates that, although complete remission and/or chimerism may be achieved in the bone marrow, chimerism achieved at the tissue level, and the subsequent GVL effect, may be limited, despite concomitant severe GVHD following allo-HSCT. Our tissue chimerism analysis results provide a good example of how skin tissue may be a 'sanctuary' site for effector cells of GVL, despite active GVHD and complete hematopoetic chimerism.
dc.identifier.citationKantarcıoğlu, B., Beköz, H. S., Duvarcı Öğret, Y., Çakır, A., Kıvanç, D., Oğuz, F. S. ... Sargın, D. (2016). Isolated extramedullary cutaneous relapse despite concomitant severe graft-vs.-host disease and tissue chimerism analysis in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: A case report. Molecular and Clinical Oncology, 5(6), 745-749. https://dx.doi.org/10.3892/mco.2016.1052
dc.identifier.doi10.3892/mco.2016.1052
dc.identifier.endpage749
dc.identifier.issn2049-9450
dc.identifier.issn2049-9469
dc.identifier.issue6
dc.identifier.startpage745
dc.identifier.urihttps://dx.doi.org/10.3892/mco.2016.1052
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3452
dc.identifier.volume5
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpandidos Publ Ltd.
dc.relation.ispartofMolecular and Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute Lymphoblastic Leukemia
dc.subjectAllogeneic Stem Cell Transplantation
dc.subjectExtramedullary Relapse
dc.subjectTissue Chimerism
dc.titleIsolated extramedullary cutaneous relapse despite concomitant severe graft-vs.-host disease and tissue chimerism analysis in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: A case report
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Kantarcioglu_Bulent.pdf
Boyut:
301.77 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu