Prognostic impact of tumor lymphocytic infiltrates in patients with breast cancer undergoing neoadjuvant chemotherapy

Basit Öğe Kaydı
dc.contributor.authorAvcı, Nilüfer
dc.contributor.authorDeligönül, Adem
dc.contributor.authorTolunay, Sahsine
dc.contributor.authorÇubukçu, Erdem
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorAltmışdörtoğlu, Özgür
dc.contributor.authorTanrıverdi, Özgür
dc.contributor.authorAksoy, Asude
dc.contributor.authorKurt, Ender
dc.contributor.authorEvrensel, Türkkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:29Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:29Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000361421900007
dc.descriptionPubMed ID: 26416041
dc.description.abstractPurpose: The presence of a pronounced tumor lymphocytic infiltrate (TLI) is deemed to reflect the presence of an immunoinflammatory response against the tumor and may thus have prognostic significance. We investigated the prognostic value of TLI detected in pathological specimens collected following neoadjuvant chemotherapy (NACT) in patients with breast cancer. Methods: 100 consecutive patients with breast cancer (mean age 47.8 +/- 11.4 years) who were scheduled to undergo anthracycline- and/or taxane-containing NACT were enrolled. Specimens collected after NACT were scored with the 4-point Klintrup scoring criteria for the presence of TLI. Results: 60 patients had low-grade TLI and 40 high-grade TLI. Comparison of the patient population according to low-grade vs high-grade TLI revealed statistically significant difference both in terms of disease-free survival (DFS) (log rank=4.28, p<0.05) and overall survival (OS) (log rank=3.96, p<0.05), with high-grade TLI patients showing a better prognosis. Multivariate Cox regression analysis identified postoperative tumor size and low-grade TLI as the two main independent adverse prognostic factors. Conclusion: High-grade TLI may interfer with tumor growth and can represent a favorable prognostic factor in women with breast cancer undergoing NACT.
dc.identifier.citationAvcı, N., Deligönül, A., Tolunay, S., Çubukçu, E., Ölmez, Ö. Ö., Altmışdörtoğlu, Ö. ... Evrensel, T. (2015). Prognostic impact of tumor lymphocytic infiltrates in patients with breast cancer undergoing neoadjuvant chemotherapy. Journal of B.U.ON., 20(4), 994-1000.
dc.identifier.endpage1000
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage994
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2988
dc.identifier.volume20
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherZerbinis Publications
dc.relation.ispartofJournal of B.U.ON.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast Cancer
dc.subjectNeoadjuvant Chemotherapy
dc.subjectPrognosis
dc.subjectTumor Lymphocytic Infiltrates
dc.titlePrognostic impact of tumor lymphocytic infiltrates in patients with breast cancer undergoing neoadjuvant chemotherapy
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
olmez, omer fatih-2015.pdf
Boyut:
264.09 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu