A case report of a malignant peripheral nerve sheath tumor of the oral cavity in neurofibromatosis type 1
| dc.authorid | 0000-0003-4904-279X | |
| dc.contributor.author | Öztürk, Özmen | |
| dc.contributor.author | Tutkun, Alper | |
| dc.date.accessioned | 2020-06-03T07:00:13Z | |
| dc.date.available | 2020-06-03T07:00:13Z | |
| dc.date.issued | 2012 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı | |
| dc.description.abstract | Patients with neurofibromatosis type 1 develop both benign and malignant tumors at an increased frequency. Most of the malignant peripheral nerve sheath tumors (MPNSTs) are considered as high-grade sarcomas originating from tissues of mesenchymal origin. It is generally accepted that MPNSTs occur in about 2% to 5% of neurofibromatosis patients. In this paper, we present a 16-year-old male patient with neurofibromatosis who developed MPNST of the retromolar area. The mass enlarged rapidly in a period of 6 weeks. The patient was treated surgically, and a tumor mass with a diameter of 7 × 6 × 4 cm was excised, but after 8 months a recurrence was observed at the same site. The sarcomatous change in a neurofibroma has an extremely poor prognosis, so patients with neurofibromatosis should be closely monitored for a possible malignancy. A rapid change in size of a preexisting neurofibroma, infiltration of the adjacent structures, intralesional hemorrhage, and pain indicate a possible malignant transformation to MPNST. | |
| dc.identifier.citation | Öztürk, Ö. ve Tutkun, A. (2012). A case report of a malignant peripheral nerve sheath tumor of the oral cavity in neurofibromatosis type 1. Case Reports in Otolaryngology, 2012. https://dx.doi.org/10.1155/2012/936735 | |
| dc.identifier.doi | 10.1155/2012/936735 | |
| dc.identifier.issn | 2090-6765 | |
| dc.identifier.issn | 2090-6773 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/5251 | |
| dc.identifier.uri | https://dx.doi.org/10.1155/2012/936735 | |
| dc.identifier.volume | 2012 | |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Hindawi Publishing Corporation | |
| dc.relation.ispartof | Case Reports in Otolaryngology | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject | Malignant Peripheral Nerve Sheath Tumor | |
| dc.subject | Oral Cavity | |
| dc.subject | Neurofibromatosis | |
| dc.title | A case report of a malignant peripheral nerve sheath tumor of the oral cavity in neurofibromatosis type 1 | |
| dc.type | Article |
