Effects of transcranial and trans-spinal direct current stimulation combined with robot-assisted gait training on gait and fatigue in patients with multiple sclerosis a double-blind, randomized, sham-controlled study

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dc.contributor.authorCinbaz, Gülser
dc.contributor.authorSarı, Zübeyir
dc.contributor.authorOğuz, Semra
dc.contributor.authorTombul, Temel
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorFernández Pérez, Juan
dc.contributor.authorGómez Soriano, Julio
dc.date.accessioned2026-01-09T14:10:05Z
dc.date.available2026-01-09T14:10:05Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractBackground/Objectives: Multiple Sclerosis (MS) is a chronic neurological condition that impairs motor and sensory functions, particularly gait. Non-invasive neuromodulation techniques aim to enhance functional recovery and motor–cognitive outcomes, though their effectiveness remains debated. This study compared the effects of transcranial direct current stimulation (tDCS) and trans-spinal direct current stimulation (tsDCS), combined with robotic-assisted gait training (RAGT), on motor function and fatigue in people with MS (pwMS). Methods: This double-blind, randomized, sham-controlled clinical trial included 35 pwMS, who participated in 12 sessions of 20 min anodal tDCS (n = 11), cathodal tsDCS (n = 12), or sham treatment (n = 12), in addition to RAGT. Primary outcomes were assessed using the Timed 25-foot Walk (T25-FW), Timed Up and Go (TUG), walking speed, and Multiple Sclerosis Walking Scale-12 (MSWS-12). Fatigue was assessed with the Fatigue Severity Scale (FSS) and the Fatigue Impact Scale (FIS). ClinicalTrials number: NCT06121635. Results: Significant improvements in gait speed, T25-FW, MSWS-12, TUG scores, and fatigue (FSS) favored tDCS and tsDCS over sham stimulation. While no differences were found between tDCS and tsDCS, the tsDCS group showed a significant improvement in the FIS physical subscale compared to sham, unlike the tDCS group. Conclusions: tDCS and tsDCS, combined with RAGT, improve walking and reduce fatigue in pwMS, highlighting their potential in motor rehabilitation.
dc.identifier.citationCinbaz, G., Sarı, Z., Oğuz, S., Tombul, T., Hanoğlu, L., Fernández Pérez, J. ... Gómez Soriano, J. (2024). Effects of transcranial and trans-spinal direct current stimulation combined with robot-assisted gait training on gait and fatigue in patients with multiple sclerosis a double-blind, randomized, sham-controlled study. Journal of Clinical Medicine, 13(24). http://dx.doi.org/10.3390/jcm13247632
dc.identifier.doi10.3390/jcm13247632
dc.identifier.issn2077-0383
dc.identifier.issue24
dc.identifier.pmid39768555
dc.identifier.scopus2-s2.0-85213287273
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.3390/jcm13247632
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13364
dc.identifier.volume13
dc.identifier.wosWOS:001386945000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorid0000-0003-4292-5717
dc.language.isoen
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGait
dc.subjectMultiple Sclerosis
dc.subjectNeurological Rehabilitation
dc.subjectTrans-Spinal Direct Current Stimulation
dc.subjectTranscranial Direct Current Stimulation
dc.titleEffects of transcranial and trans-spinal direct current stimulation combined with robot-assisted gait training on gait and fatigue in patients with multiple sclerosis a double-blind, randomized, sham-controlled study
dc.typeArticle

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