The impact of sarcopenia on morbidity and long-term survival among patients with peritoneal metastases of colorectal origin treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a 10-year longitudinal analysis of a single-center experience

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dc.authorid0000-0002-2282-7207
dc.contributor.authorA?alar, Cihan
dc.contributor.authorSökmen, Selman
dc.contributor.authorArslan, Çi?dem
dc.contributor.authorTuncer Altay, Canan
dc.contributor.authorBaşara, Işıl
dc.contributor.authorCanda, Aras Emre
dc.contributor.authorObuz, Funda
dc.date.accessioned2020-04-15T06:51:51Z
dc.date.available2020-04-15T06:51:51Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractBackground The aim of this study was to evaluate the prognostic value of preoperative sarcopenia with regard to postoperative morbidity and long-term survival in patients with peritoneal metastasis from colorectal cancer treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Methods A longitudinal cohort study was conducted on patients with peritoneal metastases of colorectal origin treated with CRS-HIPEC between 2008 and 2018. Data on patient demographics, body mass index, operative characteristics, perioperative morbidity and survivorship status and oncological follow-up were obtained from the hospital registry. Sarcopenia was assessed using preoperative computed tomography (CT) findings. Results Sixty-five patients [mean (SD) age: 54.4 (13.4) years, 64.6% females] were included in the study. Sarcopenia was evident in 30.8% of patients, while mortality rate was 66.2% with median survival time of 33.6 months. Presence of sarcopenia was associated with older age (59.6 (9.2) vs. 52.1 (14.4) years, p = 0.038), higher likelihood of morbidity (70.0% vs. 35.6%, p = 0.015) and mortality (90.0% vs. 55.6%, p = 0.010) and shorter survival time (17.7 vs. 37.9 months, p = 0.005). Cox regression analysis revealed that the presence of sarcopenia (HR 2.245, 95% CI 0.996-5.067, p = 0.050) was a significant predictor of increased likelihood of mortality. Conclusions Preoperative sarcopenia is an independent prognostic factor of postoperative morbidity and shorter survival in CRC peritoneal metastasis patients treated with CRS-HIPEC. Our findings support the importance of preoperative screening for sarcopenia as part of preoperative risk assessment for better selection of CRS-HIPEC candidates or treatment modifications in CRC patients with peritoneal metastasis.
dc.identifier.citationA?alar, C., Sökmen, S., Arslan, Ç., Tuncer Altay, C., Başara, I., Canda, A. E. ... Obuz, F. (2020). The impact of sarcopenia on morbidity and long-term survival among patients with peritoneal metastases of colorectal origin treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a 10-year longitudinal analysis of a single-center experience. Techniques in Coloproctology, 24(4), 301-308. https://dx.doi.org/10.1007/s10151-020-02159-z
dc.identifier.doi10.1007/s10151-020-02159-z
dc.identifier.endpage308
dc.identifier.issn1123-6337
dc.identifier.issn1128-045X
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage301
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5118
dc.identifier.urihttps://dx.doi.org/10.1007/s10151-020-02159-z
dc.identifier.volume24
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofTechniques in Coloproctologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectColorectal Cancer
dc.subjectPeritoneal Metastases
dc.subjectHIPEC
dc.subjectLong-Term Outcomes
dc.subjectPeritoneal Carcinomatosis
dc.subjectSarcopenia
dc.titleThe impact of sarcopenia on morbidity and long-term survival among patients with peritoneal metastases of colorectal origin treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a 10-year longitudinal analysis of a single-center experience
dc.typeArticle

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