Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study

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dc.contributor.authorAltınok Yıldırım, Ayşe
dc.contributor.authorYıldırım, Şükrü
dc.contributor.authorAltuğ, Tuncay
dc.contributor.authorSüt, Necdet Hilmi
dc.contributor.authorÖber, Ahmer
dc.contributor.authorÖzşahin, Esat Mehmet
dc.contributor.authorAzria, David
dc.contributor.authorBeşe Şenel, Nuran
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:41Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:41Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.descriptionIEEE Conference on Standards for Communications and Networking, CSCN 2015 -- 28 October 2015 through 30 October 2015 -- 119154
dc.description.abstractPurpose: In experimental and clinical trials, tamoxifen (TAM) has been shown to increase radiation-induced lung fibrosis (RILF). Furthermore, aromatase inhibitors (AI) have been shown to be superior to TAM in the adjuvant setting and preclinical data suggest that letrozole (LET) sensitizes breast cancer cells to ionizing radiation in other studies. In this experimental study, we evaluated whether AI have any impact on the development of RILF in rats. Materials and methods: 60 female wistar- albino rats were divided into 6 groups: Control (group A), RT alone (group B), RT + TAM (group C), RT + anastrozole (ANA group D), RT + LET (group E), and RT + exemestane (EXE, group F). RT consisted of 30 Gy in 10 fractions to both lungs with an anterior field at 2 cm depth. Equivalent doses for 60 kg adult dose per day of TAM, ANA, LET, and EXE were calculated according to the mean weight of rats and orally administrated with a feeding tube. Percentage of lung with fibrosis was quantified with image analysis of histological sections of the lung. The mean score values were calculated for each group. the significance of the differences among groups were calculated using one way ANOVA test and Tukey HSD post-hoc test. Results: Mean values of fibrosis were 1.7, 5.9, 6.7, 2.5, 2 and 2.2 for groups A, B, C, D, E, and F, respectively (p = 0.000). TAM increased RT-induced lung fibrosis but without statistical significance. Groups treated with RT + AI showed significantly less lung fibrosis than groups treated with RT alone or RT + TAM (p = 0.000). RT + AI groups showed nearly similar RT-induced lung fibrosis than control group. Conclusions: In this study, we found that AI decreased RT-induced lung fibrosis to the control group level suggesting protective effect.
dc.identifier.citationAltınok Yıldırım, A., Yıldırım, Ş., Altuğ, T., Süt, N. H., Öber, A., Özşahin, E. M. ... Beşe Şenel, N. (2016). Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study. Breast, 28, 174-177. https://dx.doi.org/10.1016/j.breast.2016.04.003
dc.identifier.doi10.1016/j.breast.2016.04.003
dc.identifier.endpage177
dc.identifier.issn0960-9776
dc.identifier.scopusqualityQ1
dc.identifier.startpage174
dc.identifier.urihttps://hdl.handle.net/20.500.12511/904
dc.identifier.urihttps://dx.doi.org/10.1016/j.breast.2016.04.003
dc.identifier.volume28
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofBreasten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAromatase Inhibitors
dc.subjectBreast Cancer
dc.subjectRadiation Therapy
dc.subjectRadioprotective Effect
dc.titleAromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study
dc.typeArticle

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