The immunostimulatory effect of lactic acid bacteria in a rat model

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dc.authorid0000-0002-0060-2859
dc.contributor.authorKarameşe, Murat
dc.contributor.authorAydın, Hakan
dc.contributor.authorŞengül, Emin
dc.contributor.authorGelen, Volkan
dc.contributor.authorSevim, Çiğdem
dc.contributor.authorÜstek, Duran
dc.contributor.authorKarakuş, Emre
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:04Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:04Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.descriptionWOS: 000390674400007
dc.descriptionPubMed ID: 27671513
dc.description.abstractBackground: Probiotics are "live", beneficial microbes that provide important health benefits in their hosts. There is significant interest in the modulation and regulation of the immune function by probiotics. Objective: To investigate the immunomodulatory effects of a probiotic mixture, including Lactobacillus and Bifidobacterium species, by detecting serum cytokine and immunoglobulin levels. Methods: The rats were randomly divided into 4 groups. The first group was "Control group" and other 3 groups were probiotic application groups who received different doses of probiotics. The probiotic mixture included 12 probiotic bacteria, mostly Lactobacillus and Bifidobacterium strains. Probiotic mixture was administered to rats for 12 consecutive days. TNF-alpha, TGF-beta, IL-1-beta, IL-6, and IL-10 levels as well as serum IgG and IgA concentrations were detected in the sera after 12 days. Results: Probiotics led to a decrease in the levels of TNF-alpha, IL-6 and TGF-beta; however, they led to increase in the serum levels of IL-10, IgG and IgA. There were significant differences between control group and probiotic application groups (p<0.05). Conclusion: These data suggest that the commensal microbiota are important for stimulating both proinflammatory and regulatory responses in order to rapidly clear infections and minimize inflammation-associated tissue damage.
dc.description.sponsorshipKafkas University, Scientific Research Project Council [2016-TS-43]en_US
dc.description.sponsorshipThanks for Dr. Ismail CAN for invaluable support to some steps of the experiments and methods. The current study was supported by Kafkas University, Scientific Research Project Council under the project number: 2016-TS-43.en_US
dc.identifier.citationKarameşe, M., Aydın, H., Şengül, E., Gelen, V., Sevim, Ç., Üstek, D. ... Karakuş, E. (2016). The immunostimulatory effect of lactic acid bacteria in a rat model. Iranian Journal of Immunology, 13(3), 220-228.
dc.identifier.endpage228
dc.identifier.issn1735-1383
dc.identifier.issn1735-367X
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage220
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2890
dc.identifier.volume13
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherShiraz Inst Cancer Res
dc.relation.ispartofIranian Journal of Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBifidobacterium
dc.subjectCytokines
dc.subjectImmunomodulation
dc.subjectLactobacillus
dc.subjectProbiotics
dc.titleThe immunostimulatory effect of lactic acid bacteria in a rat model
dc.typeArticle

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