Polyamine metabolism and obesity: Polyamine metabolic enzymes involved in obesity

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dc.contributor.authorBüyükuslu, Nihal
dc.contributor.authorÖztürk, Rabia İclal
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:11Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:11Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractThe natural polyamines, putrescine, spermidine and spermine are distributed widely in all cells including adipocytes. They are involved in several physiological processes involving gene expression and cell proliferation. The body pool of polyamines is maintained by endogenous biosynthesis, intestinal microorganisms and the diet. A correlation between fat metabolism and polyamine metabolism has been reported in several studies. It was shown that the inhibition of polyamine metabolism enzymes had been associated with increased adipose tissue and weight gain in human and animal models. Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) are anabolic enzymes; and spermidine/ spermine N1-acetyltransferase (SSAT) and polyamine oxidase (PAO) are catabolic enzymes which regulate polyamine homoeostasis. Genetically altered polyamine metabolic enzymes resulted in higher tissue adipose content and weight gain indicating potential links between obesity and polyamine metabolism. This review aims to provide details on previously reported sources of data published on polyamine metabolism and obesity.
dc.identifier.citationBüyükuslu, N. ve Öztürk, R. İ. (2018). Polyamine metabolism and obesity: Polyamine metabolic enzymes involved in obesity. Acta Pharmaceutica Sciencia, 56(2), 85-91. https://dx.doi.org/10.23893/1307-2080.APS.05613
dc.identifier.doi10.23893/1307-2080.APS.05613
dc.identifier.endpage91
dc.identifier.issn1307-2080
dc.identifier.issue2
dc.identifier.scopusqualityQ4
dc.identifier.startpage85
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1086
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05613
dc.identifier.volume56
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherİstanbul Medipol University
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPolyamine
dc.subjectObesity
dc.subjectOrnithine Decarboxylase
dc.subjectS-Adenosylmethionine Decarboxylase
dc.subjectSpermidine/Spermine N1-Acetyltransferase
dc.subjectPolyamine Oxidase
dc.titlePolyamine metabolism and obesity: Polyamine metabolic enzymes involved in obesity
dc.typeArticle

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