Emerin expression in well differentiated epithelial lesions of thyroid: Implications in papillary thyroid carcinoma diagnosis and predicting malignant behavior

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dc.authorid0000-0003-0128-6947
dc.contributor.authorÇoban, İpek
dc.contributor.authorErdoğan Çakır, Aslı
dc.contributor.authorKökenek Ünal, Tuba Dilay
dc.contributor.authorBaşsüllü, Nuray
dc.contributor.authorKarpuz, Vildan
dc.contributor.authorBülbül Do?usoy, Gülen
dc.contributor.authorAlper, Murat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:22Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:22Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000354265700016
dc.descriptionPubMed ID: 25116851
dc.description.abstractRecently, it has been reported that identifying nuclear membrane irregularities with anti-emerin antibody is useful for papillary thyroid carcinoma diagnosis. However, literature regarding the significance of emerin immunohistochemistry in thyroid is limited. We evaluated the diagnostic accuracy of the well-established nuclear alterations, nuclear protrusions and recently described nuclear shapes (garlands and star-like shapes) with emerin immunohistochemistry and hematoxylin- eosin stain in thyroid lesions. We further evaluated the diagnostic accuracy measures of tissue microarrays evaluated with both stains, to detect whether emerin immunohistochemistry improves the diagnostic accuracy for papillary thyroid carcinoma. For papillary thyroid carcinoma, pseudo- inclusions were best performers with emerin (diagnostic accuracy: 0.91), whereas with hematoxylin- eosin diagnostic accuracy of grooves was the highest (0.92). For follicular variant of papillary thyroid carcinoma, with both stains, predominately oval nuclear shape had the best diagnostic performance (diagnostic accuracy: 0.95). Nuclear protrusions were poor identifiers for papillary thyroid carcinoma. However, with emerin immunohistochemistry, they could successfully identify malignancy in 83 % of the cases. Using emerin immunohistochemistry, in addition to hematoxylin- eosin improved the diagnostic accuracy for papillary thyroid carcinoma when compared to hematoxylin- eosin evaluation only (sensitivity: 0.70 vs 0.86, negative predictive value: 0.81 vs. 0.94, diagnostic accuracy: 0.87 vs. 0.94). Consistent with the previous literature, our findings indicate that emerin immunohistochemistry may be used as an adjunct diagnostic method to identify papillary thyroid carcinoma. Additionally, we suggest that nuclear protrusions detected with emerin imunohistochemistry may be used as indicators of malignant behavior in small tissue samples of thyroid.
dc.identifier.citationÇoban, İ., Erdoğan Çakır, A., Kökenek Ünal, T. D., Başsüllü, N., Karpuz, V., Bülbül Do?usoy, G. ve Alper, M. (2015). Emerin expression in well differentiated epithelial lesions of thyroid: Implications in papillary thyroid carcinoma diagnosis and predicting malignant behavior. Pathology and Oncology Research, 21(2), 357-366. https://dx.doi.org/10.1007/s12253-014-9828-0
dc.identifier.doi10.1007/s12253-014-9828-0
dc.identifier.endpage366
dc.identifier.issn1219-4956
dc.identifier.issn1532-2807
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage357
dc.identifier.urihttps://dx.doi.org/10.1007/s12253-014-9828-0
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3631
dc.identifier.volume21
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPathology and Oncology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEmerin
dc.subjectThyroid
dc.subjectNucleus
dc.subjectMembrane
dc.titleEmerin expression in well differentiated epithelial lesions of thyroid: Implications in papillary thyroid carcinoma diagnosis and predicting malignant behavior
dc.typeArticle

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