Registry-based retrospective cohort study of mortality among adults admitted to intensive care units in İstanbul with hospital acquired pseudomonas aeruginosa bloodstream-infection between 2014–2021

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dc.authorid0000-0001-6311-5428
dc.authorid0000-0003-4147-3587
dc.authorid0000-0001-8945-2385
dc.contributor.authorDerin, Okan
dc.contributor.authorŞahin, Meyha
dc.contributor.authorDumlu, Rıdvan
dc.contributor.authorBaşgönül, Sedef
dc.contributor.authorBayrak, Ahmet Doğukan
dc.contributor.authorArduç, Şevval
dc.contributor.authorBayram, Sümeyye
dc.contributor.authorMikaliyova, Nurlana
dc.contributor.authorKantürk, Arzu
dc.contributor.authorÖncül, Ahsen
dc.contributor.authorYıldız Sevgi, Dilek
dc.contributor.authorGençer, Serap
dc.contributor.authorBayraktar, Banu
dc.contributor.authorDökmetaş, İlyas
dc.contributor.authorMert, Ali
dc.date.accessioned2024-02-02T10:28:12Z
dc.date.available2024-02-02T10:28:12Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Epidemiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Managing Pseudomonas aeruginosa bloodstream infections (BSIs) is challenging due to increasing antimicrobial resistance, limited therapeutic options, and high mortality rates. In this study, we aimed to identify 30-day mortality risk factors and assess infectious diseases consultants’ preferences for combination or monotherapy. Methods: The study was conducted in four hospitals in Istanbul, Turkey, involving 140 adult ICU beds and 336,780 ICU-bed-days between 1 January 2014, and 31 December 2021. A total of 157 patients were included in the study. Cox proportional hazard regression was performed to assess the factors on 30-day mortality. Results: The 30-day mortality rate was 44.6% (70/157). Higher Charlson Comorbidity Index (CCI) score, severe sepsis, primary bloodstream infection, being in COVID-19 pandemic period, and infection caused by MDR strain were associated with higher hazard of 30-day mortality. Combination therapy was more commonly used in patients with BSIs with MDR or DTR (difficult-to-treat) strains but did not significantly improve the hazard of 30-day mortality. Conclusions: Targeted interventions and vigilant management strategies are crucial for patients with defined risk factors. While infectious disease consultants tended to favor combination therapy, particularly for drug-resistant strains, our analysis revealed no significant impact on 30-day mortality hazard. The increased incidence of P. aeruginosa BSIs during the pandemic emphasizes the need for infection control measures and appropriate antibiotic prescribing practices.
dc.identifier.citationDerin, O., Şahin, M., Dumlu, R., Başgönül, S., Bayrak, A. D., Arduç, Ş. ... Mert, A. (2024). Registry-based retrospective cohort study of mortality among adults admitted to intensive care units in İstanbul with hospital acquired pseudomonas aeruginosa bloodstream-infection between 2014–2021. Antibiotics, 13(1). https://dx.doi.org/10.3390/antibiotics13010090
dc.identifier.doi10.3390/antibiotics13010090
dc.identifier.issn2079-6382
dc.identifier.issue1
dc.identifier.pmid38247649
dc.identifier.scopus2-s2.0-85183175029
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3390/antibiotics13010090
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12243
dc.identifier.volume13
dc.identifier.wos001151767300001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDerin, Okan
dc.institutionauthorŞahin, Meyha
dc.institutionauthorMikaliyova, Nurlana
dc.institutionauthorMert, Ali
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofAntibioticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectBloodstream Infections
dc.subjectIntensive-Care Units
dc.subjectPseudomonas
dc.titleRegistry-based retrospective cohort study of mortality among adults admitted to intensive care units in İstanbul with hospital acquired pseudomonas aeruginosa bloodstream-infection between 2014–2021
dc.typeArticle

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