The changing of serum vitamin B-12 and homocysteine levels after gastrectomy in patients with gastric cancer: do they associate with clinicopathological factors?

Basit Öğe Kaydı
dc.contributor.authorBilici, Ahmet
dc.contributor.authorSonkaya, Alper
dc.contributor.authorErcan, Şerif
dc.contributor.authorUstaalioğlu, Bala Başak Öven
dc.contributor.authorŞeker, Mesut
dc.contributor.authorAliustao?lu, Mehmet
dc.contributor.authorOrçun, Asuman
dc.contributor.authorGümüş, Mahmut
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:24Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:24Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000350478200042
dc.descriptionPubMed ID: 25296737
dc.description.abstractAfter total (TG) or distal subtotal gastrectomy (DG), patients are at high risk of vitamin B-12 (vit-B-12) deficiency, which results in elevation of homocysteine levels. The changing of serum vit-B-12 and homocysteine levels in patients with gastric cancer is not well known. Seventy-two patients with gastric cancer who had undergone currative gastrectomy and 50 healthy controls were included. Serum vit-B-12 and homocysteine levels were analyzed in gastric cancer patients. In addition, these parameters were compared with those of healthy control subjects. While serum vit-B-12 levels in gastrectomized patients were significantly lower than that of healthy controls (221.8 +/- 125.6 pg/mL vs. 309.9 +/- 174.3 pg/mL, p = 0.002), homocysteine levels were significantly higher in patients with gastric cancer (14.2 +/- 6.7 mu mol/L vs. 12.5 +/- 6.1 mu mol/L, p = 0.016). Mean serum folate level was found to be high in healthy controls (7.3 ng/mL) compared to patients (9.2 ng/mL, p = 0.027). Out of 72 patients, 40 patients (55.6 %) with gastric cancer developed vit-B-12 deficiency after gastrectomy. Vit-B-12 deficiency was found to be related with gastrectomy type (p = 0.02) and homocysteine levels (p = 0.014). In patients who underwent TG, the incidence of vit-B-12 deficiency was significantly higher compared with those with DG (67.5 vs. 32.5 %). In addition, serum vit-B-12 level in patients with DG was significantly higher than that of patients with TG (248.3 +/- 122.0 pg/mL vs. 200.8 +/- 126.7 pg/mL, p = 0.041), whereas homocysteine levels were significantly lower in DG group compared with TG group (12.1 +/- 6.1 mu mol/L vs. 15.8 +/- 6.9 mu mol/L, p = 0.014). A logistic regression analysis showed that the extent of gastrectomy was found to be an independent factor for predicting the occurrence of vit-B-12 deficiency (p < 0.001, odds ratio 1.38). Our results showed that cumulative vit-B-12 deficiency rate was significantly higher after TG compared with that after DG, while homocysteine levels were significantly higher in TG group compared with DG group. The extent of gastrectomy was found to be an independent factor for predicting the occurrence of vit-B-12 deficiency. Vit-B-12 deficiency and hyperhomocysteinemia are imperious clinical situation for patients with gastric cancer after surgery. Hence, both preoperative and regular postoperative monitoring of vit-B-12 and homocysteine levels for all gastrectomized patients with gastric cancer are important and necessary for early detection and prevention of vit-B-12 deficiency and hyperhomocysteinemia as a risk factor for cardiovascular diseases.
dc.identifier.citationBilici, A. E., Sonkaya, A., Ercan, Ş., Ustaalioğlu, B. B. Ö., Şeker, M., Aliustao?lu, M. ...Gümüş, M. (2015). The changing of serum vitamin B-12 and homocysteine levels after gastrectomy in patients with gastric cancer: do they associate with clinicopathological factors? Tumor Biology, 36(2), 823-828. https://dx.doi.org/10.1007/s13277-014-2705-3
dc.identifier.doi10.1007/s13277-014-2705-3
dc.identifier.endpage828
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue2
dc.identifier.scopusqualityQ1
dc.identifier.startpage823
dc.identifier.urihttps://dx.doi.org/10.1007/s13277-014-2705-3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3868
dc.identifier.volume36
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofTumor Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectVitamin B-12
dc.subjectHomocysteine
dc.subjectGastrectomy
dc.subjectGastric Cancer
dc.titleThe changing of serum vitamin B-12 and homocysteine levels after gastrectomy in patients with gastric cancer: do they associate with clinicopathological factors?
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
bilici, ahmet-2015.pdf
Boyut:
194.53 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu