Disturbed endometrial NF-?B expression in women with recurrent implantation failure

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dc.contributor.authorErşahin, Aynur Adeviye
dc.contributor.authorAcet, Mustafa
dc.contributor.authorAcet, Tuba
dc.contributor.authorYavuz, Yasemin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:51Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:51Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractOBJECTIVE: This study was planned to investigate whether expression levels of endometrial NF-?B1 and NF?B p65 changes in women with recurrent implantation failure (RIF). PATIENTS AND METHODS: The study group consists of 30 RIF patients having at least three previous failed IVF cycles. The control group comprises of 30 patients having one or no previous failed attempt. Endometrial samples were obtained from all participants during hysteroscopy at the late follicular phase. Samples underwent ELISA analysis and immunohistochemical staining. The semi-quantitative H-Score method was used for analyzing the intensity of endometrial NF-?B p65 expression. RESULTS: The concentrations of endometrial NF-?B1 were found to be significantly increased when compared to control subjects. Likewise, significantly increased NF-?B p65 immunoreactivity was detected in the cytoplasm of luminal and glandular epithelial cells. The H-Score of NF- ?B p65 in RIF women was found to be significantly increased when compared to control group. CONCLUSIONS: Increased levels of NF-?B1 and NF-?B p65 in the endometrium of RIF women can disturb physiological inflammation which is known to be positive modulator of endometrial receptivity.
dc.identifier.citationErşahin, A. A., Acet, M., Acet, T. ve Yavuz, Y. (2016). Disturbed endometrial NF-?B expression in women with recurrent implantation failure. European Review for Medical and Pharmacological Sciences, 20(24), 5037-5040.
dc.identifier.endpage5040
dc.identifier.issn1128-3602
dc.identifier.issue24
dc.identifier.scopusqualityQ2
dc.identifier.startpage5037
dc.identifier.urihttps://hdl.handle.net/20.500.12511/971
dc.identifier.volume20
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInflammation
dc.subjectNF-?B p65
dc.subjectNF-?B1
dc.subjectRIF
dc.titleDisturbed endometrial NF-?B expression in women with recurrent implantation failure
dc.typeArticle

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