Proteomic analysis of kidney preservation solutions prior to renal transplantation

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dc.contributor.authorÇoşkun, Abdurrahman
dc.contributor.authorBaykal, Ahmet Tarık
dc.contributor.authorKazan, Dilek
dc.contributor.authorAkgöz, Müslüm
dc.contributor.authorŞenal Öztuğ, Merve
dc.contributor.authorBerber, İbrahim
dc.contributor.authorTitiz, İzzet
dc.contributor.authorBilsel, Gökhan
dc.contributor.authorKilercik, Hakan
dc.contributor.authorKaraosmanoğlu, Kübra
dc.contributor.authorÇiçek, Müslüm
dc.contributor.authorYurtsever, İlknur
dc.contributor.authorYazıcı, Cevat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:36Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:36Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000391229300025
dc.descriptionPubMed ID: 28036361
dc.description.abstractOne of the main issues in kidney transplantation is the optimal functional preservation of the organ until its transplantation into the appropriate recipient. Despite intensive efforts, the functional preservation period remains limited to hours. During this time, as a result of cellular injury, various proteins, peptides, and other molecules are released by the organ into the preservation medium. In this study, we used proteomic techniques to analyze the protein profiles of preservation solutions in which organs had been preserved prior to their transplantation. Samples were obtained from the preservation solutions of 25 deceased donor kidneys scheduled for transplantation. The protein profiles of the solutions were analyzed using 2D gel electrophoresis/MALDI-TOF and LC-MS/MS. We identified and quantified 206 proteins and peptides belonging to 139 different groups. Of these, 111 proteins groups were belonging to kidney tissues. This study used proteomic techniques to analyze the protein profiles of organ preservation solutions. These findings will contribute to the development of improved preservation solutions to effectively protect organs for transplantation.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [110S103]en_US
dc.description.sponsorshipThis study was financed by The Scientific and Technological Research Council of Turkey (TUBITAK), project number 110S103, http://www.tubitak.gov.tr/en. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.citationÇoşkun, A., Baykal, A. T., Kazan, D., Akgöz, M., Şenal, M. Ö., Berber, İ. ... Yazıcı, C. (2016). Proteomic analysis of kidney preservation solutions prior to renal transplantation. Plos One, 11(12). https://dx.doi.org/10.1371/journal.pone.0168755
dc.identifier.doi10.1371/journal.pone.0168755
dc.identifier.issn1932-6203
dc.identifier.issue12
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1371/journal.pone.0168755
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3690
dc.identifier.volume11
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectProteomic
dc.subjectKidney Transplantation
dc.subjectPreservation Solutions
dc.titleProteomic analysis of kidney preservation solutions prior to renal transplantation
dc.typeArticle

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