Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0002-7715-3035
dc.authorid0000-0003-4292-5717
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorFerri, Raffaele
dc.contributor.authorLizio, Roberta
dc.contributor.authorLopez, Susanna
dc.contributor.authorLorenzo, Ivan
dc.contributor.authorTucci, Federico
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorZurrón, Montserrat
dc.contributor.authorDíaz, Fernando
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFamà, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorCipollini, Virginia
dc.contributor.authorMarizzoni, Moira
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorYıldırım, Ebru
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.contributor.authorHünerli Gündüz, Duygu
dc.contributor.authorOnorati, Paolo
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorVacca, Laura
dc.contributor.authorMaestú, Fernando
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authordel Percio, Claudio
dc.date.accessioned2023-01-11T09:13:53Z
dc.date.available2023-01-11T09:13:53Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractIn the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (A beta 42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.
dc.description.sponsorshipMinistry of Health, Italyen_US
dc.identifier.citationBabiloni, C., Noce, G., Ferri, R., Lizio, R., Lopez, S., Lorenzo, I. ... del Percio, C. (2022). Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study. Cerebral Cortex, 32(10), 2197-2215. https://dx.doi.org/10.1093/cercor/bhab348
dc.identifier.doi10.1093/cercor/bhab348
dc.identifier.endpage2215
dc.identifier.issn1047-3211
dc.identifier.issn1460-2199
dc.identifier.issue10
dc.identifier.pmid34613369
dc.identifier.scopus2-s2.0-85128377064
dc.identifier.scopusqualityQ1
dc.identifier.startpage2197
dc.identifier.urihttps://dx.doi.org/10.1093/cercor/bhab348
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10284
dc.identifier.volume32
dc.identifier.wos000789377200001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüntekin, Bahar
dc.institutionauthorYıldırım, Ebru
dc.institutionauthorHanoğlu, Lütfü
dc.language.isoen
dc.publisherOxford University Press Inc
dc.relation.ispartofCerebral Cortexen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectExact Low-Resolution Brain Electromagnetic Source Tomography (eLORETA)
dc.subjectMild Cognitive Impairment due to Alzheimer’s Disease (ADMCI)
dc.subjectResting State Electroencephalographic (rsEEG) Rhythms
dc.subjectSex
dc.titleResting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study
dc.typeArticle

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