Non-neoplastic polyps of the gallbladder: A clinicopathologic analysis of 447 cases

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dc.authorid0000-0001-6830-7701
dc.contributor.authorTaşkın, Orhun
dc.contributor.authorBellolio, Enrique
dc.contributor.authorDursun, Nevra
dc.contributor.authorErbarut Seven, İpek
dc.contributor.authorRoa, Juan C.
dc.contributor.authorAraya, Juan C.
dc.contributor.authorVillaseca, Miguel
dc.contributor.authorTapia, Oscar
dc.contributor.authorVance, Courtney
dc.contributor.authorSaka, Burcu
dc.contributor.authorBalcı, Serdar
dc.contributor.authorBağcı, Pelin
dc.contributor.authorLosada, Hector
dc.contributor.authorSarmiento, Juan
dc.contributor.authorMemis, Bahar
dc.contributor.authorPehlivanoğlu, Burçin
dc.contributor.authorBaştürk, Olca
dc.contributor.authorReid, Michelle D.
dc.contributor.authorKoshiol, Jill
dc.contributor.authorCheng, Jeanette
dc.contributor.authorKapran, Yersu
dc.contributor.authorAdsay, Volkan
dc.date.accessioned2020-03-23T12:01:40Z
dc.date.available2020-03-23T12:01:40Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractThere is no systematic histopathologic analysis of non-neoplastic polyps in the gallbladder. In this study, in addition to a computer search for cases designated as "polyp," a systematic review of 2533 consecutive routinely sampled archival and 203 totally submitted prospective cholecystectomies were analyzed for >2?mm polyps (cut-off was based on radiologic sensitivity). A total of 447 non-neoplastic polyps were identified. The frequency was 3% in archival cases and 5% in totally submitted cases. Only 21 (5%) were ?1?cm. The average age was 52 years, and the female to male ratio was 3.1. Two distinct categories were delineated: (1) injury-related polyps (n=273): (a) Fibro(myo)glandular polyps (n=214) were small (mean=0.4?cm), broad-based, often multiple (45%), almost always (98%) gallstone-associated, and were composed of a mixture of (myo)fibroblastic tissue/lobular glandular units with chronic cholecystitis. Dysplasia seen in 9% seemed to be secondary involvement. (b) Metaplastic pyloric glands forming polypoid collections (n=42). (c) Inflammatory-type polyps associated with acute/subacute injury (11 granulation tissue, 3 xanthogranulomatous, 3 lymphoid). (2) Cholesterol polyps (n=174) occurred in uninjured gallbladders, revealing a very thin stalk, edematous cores devoid of glands but with cholesterol-laden macrophages in 85%, and cholesterolosis in the uninvolved mucosa in 60%. Focal low-grade dysplasia was seen in 3%, always confined to the polyp, unaccompanied by carcinoma. In conclusion, non-neoplastic polyps are seen in 3% of cholecystectomies and are often small. Injury-related fibromyoglandular polyps are the most common. Cholesterol polyps have distinctive cauliflower architecture, often in a background of uninjured gallbladders with cholesterolosis and may lack the cholesterol-laden macrophages in the polyp itself. Although dysplastic changes can involve non-neoplastic polyps, they do not seem to be the cause of invasive carcinoma by themselves.
dc.identifier.citationTaşkın, O., Bellolio, E., Dursun, N., Erbarut Seven, İ., Roa, J. C., Araya, J. C. ... Adsay, V. (2020). Non-neoplastic polyps of the gallbladder: A clinicopathologic analysis of 447 cases. American Journal of Surgical Pathology, 44(4), 467-476. http://doi.org/10.1097/PAS.0000000000001405
dc.identifier.doi10.1097/PAS.0000000000001405
dc.identifier.endpage476
dc.identifier.issnhttp://doi.org/10.1097/PAS.0000000000001405
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage467
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5078
dc.identifier.volume44
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofAmerican Journal of Surgical Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectNon-Neoplastic Polyps
dc.subjectGallbladder
dc.subjectClinicopathologic Analysis
dc.titleNon-neoplastic polyps of the gallbladder: A clinicopathologic analysis of 447 cases
dc.typeArticle

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