Olfactory cleft measurements and COVID-19-related anosmia

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dc.authorid0000-0003-0334-811X
dc.contributor.authorAltundağ, Aytuğ
dc.contributor.authorYıldırım, Düzgün
dc.contributor.authorTekcan Şanlı, Deniz Esin
dc.contributor.authorÇayönü, Melih
dc.contributor.authorKandemirli, Sedat Giray
dc.contributor.authorŞanlı, Ahmet Necati
dc.contributor.authorArıcı Düz, Özge
dc.contributor.authorSaatçi, Özlem
dc.date.accessioned2021-06-17T07:49:40Z
dc.date.available2021-06-17T07:49:40Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractObjective. This study aimed to investigate the differences in olfactory cleft (OC) morphology in coronavirus disease 2019 (COVID-19) anosmia compared to control subjects and postviral anosmia related to infection other than severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study Design. Prospective. Setting. This study comprises 91 cases, including 24 cases with anosmia due to SARS-CoV-2, 38 patients with olfactory dysfunction (OD) due to viral infection other than SARS-CoV-2, and a control group of 29 normosmic cases. Methods. All cases had paranasal sinus computed tomography (CT), and cases with OD had magnetic resonance imaging (MRI) dedicated to the olfactory nerve. The OC width and volumes were measured on CT, and T2-weighted signal intensity (SI), olfactory bulb volumes, and olfactory sulcus depths were assessed on MRI. Results. This study showed 3 major findings: the right and left OC widths were significantly wider in anosmic patients due to SARS-CoV-2 (group 1) or OD due to non-SARS-CoV-2 viral infection (group 2) when compared to healthy controls. OC volumes were significantly higher in group 1 or 2 than in healthy controls, and T2 SI of OC area was higher in groups 1 and 2 than in healthy controls. There was no significant difference in olfactory bulb volumes and olfactory sulcus depths on MRI among groups 1 and 2. Conclusion. In this study, patients with COVID-19 anosmia had higher OC widths and volumes compared to control subjects. In addition, there was higher T2 SI of the olfactory bulb in COVID-19 anosmia compared to control subjects, suggesting underlying inflammatory changes. There was a significant negative correlation between these morphological findings and threshold discrimination identification scores.
dc.identifier.citationAltundağ, A., Yıldırım, D., Tekcan Şanlı, D. E., Çayönü, M., Kandemirli, S. G., Şanlı, A. N. ... Saatçi, Ö. (2021). Olfactory cleft measurements and COVID-19-related anosmia. Otolaryngology - Head and Neck Surgery, 164(6), 1337-1344. https://dx.doi.org/10.1177/0194599820965920
dc.identifier.doi10.1177/0194599820965920
dc.identifier.endpage1344
dc.identifier.issn0194-5998
dc.identifier.issn1097-6817
dc.identifier.issue6
dc.identifier.scopusqualityQ1
dc.identifier.startpage1337
dc.identifier.urihttps://dx.doi.org/10.1177/0194599820965920
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7209
dc.identifier.volume164
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofOtolaryngology - Head and Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectSARS-CoV-2
dc.subjectOlfactory Cleft
dc.subjectWidth
dc.subjectVolume
dc.subjectAnosmia
dc.subjectSniffin' Sticks
dc.subjectCOVID-19
dc.titleOlfactory cleft measurements and COVID-19-related anosmia
dc.typeArticle

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