Chronic neutropenia in childhood: Laboratory and clinical features

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dc.authorid0000-0002-4551-5433
dc.authorid0000-0002-9710-8653
dc.authorid0000-0002-0476-5452
dc.authorid0000-0002-9688-5223
dc.authorid0000-0002-7129-5024
dc.authorid0000-0001-6930-7148
dc.authorid0000-0001-8489-7449
dc.contributor.authorNepesov, Serdar
dc.contributor.authorYaman, Yöntem
dc.contributor.authorElli, Murat
dc.contributor.authorBayram, Nihan
dc.contributor.authorÖzdilli, Kürşat
dc.contributor.authorAyaz, Akif
dc.contributor.authorAnak, Sema
dc.date.accessioned2022-11-16T08:16:35Z
dc.date.available2022-11-16T08:16:35Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.description.abstractObjectives To describe the clinical characteristics of patients with chronic neutropenia. Methods Data of 36 patients with chronic neutropenia, who were followed up in the authors' clinic between May 2013 and May 2020, were analyzed retrospectively. Patients were diagnosed based on their clinical and laboratory characteristics. Results A total of 36 patients (23 females, 13 males) were included in the study. The mean age at diagnosis was 9.85 +/- 9.17 mo while the mean follow-up time was 21.83 +/- 20.03 mo. The mean absolute neutrophil count (ANC) at admission was 462.5 +/- 388.8 cells/mm(3) (median = 375 cells/mm(3)), and the lowest and highest ANC mean was 241.2 +/- 262.1 cells/mm(3) (median = 125 cells/mm(3)), and 1362.9 +/- 1127.9 cells/mm(3) (median = 925 cells/mm(3)), respectively. Idiopathic neutropenia was found in 28 (77.8%) patients, autoimmune neutropenia in 6 (16.7%) patients, and congenital neutropenia in 2 (5.6%) patients. Neutrophil normalization was observed in 19 (52.8%) of the patients. Conclusions Chronic neutropenia is a heterogeneous picture that presents with different clinical symptoms in childhood. The cause of neutropoenia in children is usually benign and resolves spontaneously but especially in those with severe neutropoenia genetic examination should be performed.
dc.identifier.citationNepesov, S., Yaman, Y., Elli, M., Bayram, N., Özdilli, K., Ayaz, A. ... Anak, S. (2022). Chronic neutropenia in childhood: Laboratory and clinical features. Indian Journal of Pediatrics, 89(9), 894-898. https://doi.org/10.1007/s12098-022-04104-4
dc.identifier.doi10.1007/s12098-022-04104-4
dc.identifier.endpage898
dc.identifier.issn0019-5456
dc.identifier.issn0973-7693
dc.identifier.issue9
dc.identifier.pmid35267133
dc.identifier.scopus2-s2.0-85126052557
dc.identifier.scopusqualityQ2
dc.identifier.startpage894
dc.identifier.urihttps://doi.org/10.1007/s12098-022-04104-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9970
dc.identifier.volume89
dc.identifier.wos000766996700001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorNepesov, Serdar
dc.institutionauthorYaman, Yöntem
dc.institutionauthorElli, Murat
dc.institutionauthorBayram, Nihan
dc.institutionauthorÖzdilli, Kürşat
dc.institutionauthorAyaz, Akif
dc.institutionauthorAnak, Sema
dc.language.isoen
dc.publisherSpringer India
dc.relation.ispartofIndian Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutoimmune Neutropenia
dc.subjectChronic Neutropenia
dc.subjectCongenital Neutropenia
dc.titleChronic neutropenia in childhood: Laboratory and clinical features
dc.typeArticle

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