The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder

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dc.authorid0000-0002-9704-6173
dc.authorid0000-0002-3691-5216
dc.authorid0000-0003-4292-5717
dc.contributor.authorYuluğ, Burak
dc.contributor.authorAyyıldız, Sevilay
dc.contributor.authorSayman, Dila
dc.contributor.authorKaraca, Ramazan
dc.contributor.authorİpek, Lütfiye
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorSalar, Ali Behram
dc.contributor.authorAyyıldız, Behçet
dc.contributor.authorMikuta, Christian
dc.contributor.authorYağcı, Nilay
dc.contributor.authorÖzdemir Öktem, Ece
dc.contributor.authorÖzşimşek, Ahmet
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorHanoğlu, Lütfü
dc.date.accessioned2024-02-19T12:29:35Z
dc.date.available2024-02-19T12:29:35Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractINTRODUCTIONEmotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients' descriptions of their cognitive symptoms.METHODSWe compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as "amnestic" or "nonamnestic," based on the members' subjective reports concerning their forgetfulness. We then sought to determine whether these patients would differ in terms of objective neuroimaging and cognitive findings.RESULTSThe right pulvinar exhibited altered connectivity in individuals with depression with objective cognitive impairment, a finding which was not apparent in depressive patients with subjective cognitive impairment.DISCUSSIONThe pulvinar may play a role in depression-related cognitive impairments. Connectivity network changes may differ between objective and subjective cognitive impairment in depression and may play a role in the increased risk of dementia in patients with depression.
dc.identifier.citationYuluğ, B., Ayyıldız, S., Sayman, D., Karaca, R., İpek, L., Çankaya, Ş. ... Hanoğlu, L. (2024). The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 10(1). https://dx.doi.org/10.1002/trc2.12450
dc.identifier.doi10.1002/trc2.12450
dc.identifier.issn2352-8737
dc.identifier.issue1
dc.identifier.pmid38356480
dc.identifier.scopus2-s2.0-85184501573
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1002/trc2.12450
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12287
dc.identifier.volume10
dc.identifier.wos001159624900001en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYuluğ, Burak
dc.institutionauthorSalar, Ali Behram
dc.institutionauthorHanoğlu, Lütfü
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofAlzheimer's and Dementia: Translational Research and Clinical Interventionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAmnestic Depression
dc.subjectCognition
dc.subjectDepression
dc.subjectFunctional Magnetic Resonance Imaging
dc.subjectPulvinar
dc.titleThe functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder
dc.typeArticle

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