Effect of oxytocin administration on nerve recovery in the rat sciatic nerve damage model

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dc.authorid0000-0003-3976-9530
dc.contributor.authorGümüş, Bilal
dc.contributor.authorKuyucu, Ersin
dc.contributor.authorErbaş, Oytun
dc.contributor.authorKazımoğlu, Cemal
dc.contributor.authorOltulu, Fatih
dc.contributor.authorArslan Bora, Osman
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:25Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:25Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.descriptionWOS: 000362988300001
dc.descriptionPubMed ID: 26466786
dc.description.abstractBackground: Growth factors such as nerve growth factor (NGF) and insulin-like growth factor-1 (IGF-1) have been shown to play a role in the healing process of nerve injury. Recent researches have also shown that oxytocin administration activates these growth factors of importance for the healing of nerve tissue. The objective of the present study was to evaluate the effects of oxytocin on peripheral nerve regeneration in rats. Methods: Twenty-four male Sprague-Dawley rats were underwent transection damage model on the right sciatic nerve and defective damage model on the left sciatic nerve. The animals were assigned to one of two groups: control group or treatment group (received 80 mg/kg oxytocin intraperitoneally for 12 weeks). The sciatic nerve was examined, both functionally (on the basis of climbing platform test) and histologically (on the basis of axon count), 3, 6, 9, and 12 weeks after the injury. Also, stereomicroscopic and electrophysiological evaluations were carried out. Results: Significantly greater improvements in electrophysiological recordings and improved functional outcome measures were presented in the treatment group at 12-week follow-up. Stereomicroscopic examinations disclosed prominent increases in vascularization on proximal cut edges in the oxytocin group in comparison with the control group. Higher axon counts were also found in this group. Conclusion: Intraperitoneal oxytocin administration resulted in accelerated functional, histological, and electrophysiological recovery after different sciatic injury models in rats.
dc.identifier.citationGümüş, B., Kuyucu, E., Erbaş, O., Kazımoğlu, C., Oltulu, F. ve Arslan Bora, O. (2015). Effect of oxytocin administration on nerve recovery in the rat sciatic nerve damage model. Journal of Orthopaedic Surgery and Research, 10. https://dx.doi.org/10.1186/s13018-015-0301-x
dc.identifier.doi10.1186/s13018-015-0301-x
dc.identifier.issn1749-799X
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1186/s13018-015-0301-x
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3257
dc.identifier.volume10
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBioMed Central
dc.relation.ispartofJournal of Orthopaedic Surgery and Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectOxytocin
dc.subjectSciatic Nerve
dc.subjectRat
dc.subjectNerve Regeneration
dc.titleEffect of oxytocin administration on nerve recovery in the rat sciatic nerve damage model
dc.typeArticle

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