Three-dimensional imaging of cleared human liver tissues reveals extensive fibrosis heterogeneity in non-alcoholic fatty liver disease

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dc.authorid0000-0002-1240-7233
dc.contributor.authorYiğit, Buket
dc.contributor.authorÖzgönül, Ekin
dc.contributor.authorYaman, Ömer
dc.contributor.authorUlukan, Burge
dc.contributor.authorÇetin Taş, Yağmur
dc.contributor.authorMorova, Berna
dc.contributor.authorAydın, Musa
dc.contributor.authorUysallı, Yiğit
dc.contributor.authorDemirtaş, Elif
dc.contributor.authorErkan, Mert
dc.contributor.authorGürsoy Özdemir, Yasemin
dc.contributor.authorKarahüseyinoğlu, Serçin
dc.contributor.authorYurdaydın, Cihan
dc.contributor.authorAkyıldız, Murat
dc.contributor.authorSheth, Abhishek
dc.contributor.authorKırımoğlu, Hale
dc.contributor.authorDayangaç, Murat
dc.contributor.authorFerhanoğlu, Onur
dc.contributor.authorKiraz, Alper
dc.contributor.authorZeybel, Müjdat
dc.date.accessioned2022-08-12T06:29:31Z
dc.date.available2022-08-12T06:29:31Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractBackground and aims: Liver fibrosis is a dynamic process of fibrogenesis and fibrolysis traditionally evaluated by liver biopsy. Accurate assessment of hepatic fibrosis is vital for optimal biomarker and drug development in the era of NASH clinical trials. The limitations of biopsy-based fibrosis staging include semi-quantitative assessment, sampling, and observer variability. In this study, we aimed to perform 3D imaging of optically transparent whole liver biopsy samples by light sheet fluorescence microscopy (LSFM) to quantify extra-cellular matrix proteins.
dc.identifier.citationYiğit, B., Özgönül, E., Yaman, Ö., Ulukan, B., Çetin Taş, Y., Morova, B. ... Zeybel, M. (2022). Three-dimensional imaging of cleared human liver tissues reveals extensive fibrosis heterogeneity in non-alcoholic fatty liver disease. Journal of Hematology içinde (S693-S694. ss.).
dc.identifier.endpageS694
dc.identifier.issn0168-8278
dc.identifier.issn1600-0641
dc.identifier.issueSupplement:1
dc.identifier.startpageS693
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9645
dc.identifier.volume77
dc.identifier.wos000826275103342en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.institutionauthorDayangaç, Murat
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Hematologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectLiver Tissues
dc.subjectFibrosis Heterogeneity
dc.subjectFatty Liver Disease
dc.titleThree-dimensional imaging of cleared human liver tissues reveals extensive fibrosis heterogeneity in non-alcoholic fatty liver disease
dc.typeConference Object

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