Efficacy and safety of combination of tadalafil and aspirin versus tadalafil or aspirin alone in patients with vascular erectile dysfunction: A comparative randomized prospective study

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dc.authorid0000-0002-2493-2457
dc.authorid0000-0002-4245-7506
dc.contributor.authorBayraktar, Zeki
dc.contributor.authorAlbayrak, Selami
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:32Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:32Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractPurpose: We aimed to investigate the efficacy and safety of tadalafil, aspirin, and tadalafil + aspirin combination therapy in vascular erectile dysfunction (VED). Methods: A total of 336 patients were randomly divided into four groups (group 1, aspirin 100 mg/day, 126 patients; group 2, tadalafil 5 mg/day, 72 patients; group 3, tadalafil 5 mg + aspirin 100 mg, 72 patients; group 4, placebo, 66 patients). In all groups, the changes from baseline to end point in erectile function scores on the International Index of Erectile Function (IIEF-EF) and the number of patients who answered “yes” to questions 2 and 3 of the sexual encounter profile(SEP) were compared statistically. Results: The changes in IIEF-EF scores after treatment were 7.2 ± 4.4, 7.3 ± 4.3, 7.5 ± 4.4, and 2.0 ± 4.6 for group 1 (p < 0.0001), group 2 (p < 0.0001), group 3 (p < 0.0001), and group 4 (p = 0.0204), respectively. The change in SEP-2 ratios after treatment were 36.6%, 36.9%, 41.7%, and 9.4% for group 1 (p < 0.0001), group 2 (p < 0.0001), group 3 (p < 0.0001), and group 4 (p = 0.2925), respectively. The change in SEP-3 ratios after treatment was 46.6%, 49.2%, 53.7%, and 12.5% for group 1 (p < 0.0001), group 2 (p < 0.0001), group 3 (p < 0.0001), and group 4 (p = 0.1456), respectively. In group 2, both the number of patients who reported side effects (p < 0.0001) and stopped using the drug due to side effects (p < 0.05) were significantly higher than the control and others groups. Conclusions: Successful results were obtained by tadalafil and aspirin monotherapy and tadalafil + aspirin combination therapy in patients with VED. However, the least side effect was observed in the tadalafil + aspirin group. Aspirin can be used alone in the treatment of patients with VED, or combined with tadalafil to reduce side effects and increase success.
dc.identifier.citationBayraktar, Z. ve Albayrak, S. (2019). Efficacy and safety of combination of tadalafil and aspirin versus tadalafil or aspirin alone in patients with vascular erectile dysfunction: A comparative randomized prospective study. International Urology and Nephrology, 51(9), 1491-1499. https://dx.doi.org/10.1007/s11255-019-02211-4
dc.identifier.doi10.1007/s11255-019-02211-4
dc.identifier.endpage1499
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue9
dc.identifier.scopusqualityQ2
dc.identifier.startpage1491
dc.identifier.urihttps://hdl.handle.net/20.500.12511/827
dc.identifier.urihttps://dx.doi.org/10.1007/s11255-019-02211-4
dc.identifier.volume51
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Netherlands
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntiplatelet
dc.subjectAspirin
dc.subjectErectile Dysfunction
dc.subjectTadalafil
dc.subjectTherapy
dc.titleEfficacy and safety of combination of tadalafil and aspirin versus tadalafil or aspirin alone in patients with vascular erectile dysfunction: A comparative randomized prospective study
dc.typeArticle

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