Impaired follicular development and ovulation in PCOS mouse model can rescued by rapamycin treatment

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dc.authorid0000-0002-6393-1465
dc.contributor.authorYaba, Aylin
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorAğuş, Sami
dc.contributor.authorGünalan, Elif
dc.contributor.authorYıldırım, Ecem Nur
dc.contributor.authorYılmaz, Bayram
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:28Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:28Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description34th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE) -- JUN 01-04, 2018 -- Barcelona, SPAIN
dc.descriptionWOS: 000438519902203
dc.description.abstractPolycystic ovary syndrome (PCOS) is a common and complex endocrine disorder affecting 5-10% of women in reproductive age that is characterized by hyperandrogenism, oligo- or anovulation and infertility. However the pathophysiology of PCOS still remains unknown. The mammalian target of rapamycin (mTOR) is a central component that regulates various processes including cell growth, proliferation, metabolism, and angiogenesis. mTOR signaling cascade has recently been examined in ovarian follicles where it regulates granulosa cell proliferation and differentiation. mTOR functions as two complexes, mTOR complex 1 and 2. Therefore, we hypothesized that mTORC1 and/or 2 may have important role in proliferation of theca and granulosa cells in PCOS. In the present study, we sought to determine the mTOR signaling pathway in PCOS mouse ovary. We designed 3 groups: Control (C, no treatment), PCOS (P, The injection of DHEA (6 mg/100 g BW in 0.1 ml of sesame oil) (s.c) for 20 consecutive days), Vehicle (V, daily (s.c) sesame oil alone injection). Our results showed that mTORC1 and mTORC2-mediated signaling may play a role in PCOS mouse ovary. These findings provide evidence that mTORC1 and mTORC2 may have responsibility in increased ovarian follicular cell proliferation and growth in PCOS. Consequently, these results suggest that the mTOR signaling pathways (mTORC1 and mTORC 2) may create new clinical strategies to optimize developmental competence of PCOS should target correction of the entire follicle growth, oocyte development process and anovulatory infertility in PCOS
dc.description.sponsorshipEuropean Society of Human Reproduction and Embryologyen_US
dc.identifier.citationYaba, A., Aydın, M. Ş., Ağuş, S., Günalan, E., Yıldırım, E. ve Yılmaz, B. (2018). Impaired follicular development and ovulation in PCOS mouse model can rescued by rapamycin treatment. 34th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE) içinde (462-462. ss.). Barcelona, Spain, June 01-04, 2018.
dc.identifier.endpage462
dc.identifier.issn0268-1161
dc.identifier.issn1460-2350
dc.identifier.issueSupplement: 1
dc.identifier.startpage462
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1992
dc.identifier.volume33
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherOxford University Press
dc.relation.ispartof34th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE)en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMTOR
dc.subjectPCOS
dc.subjectMouse
dc.subjectOvary
dc.titleImpaired follicular development and ovulation in PCOS mouse model can rescued by rapamycin treatment
dc.typeConference Object

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