Association of diabetes, hypertension, and their combination with basal symptoms and treatment responses in overactive bladder patients

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dc.authorid0000-0002-2027-0118
dc.authorid0000-0002-9354-0000
dc.authorid0000-0002-6308-1763
dc.contributor.authorMüderrisoğlu, A. Elif
dc.contributor.authorSakul, Ayse A.
dc.contributor.authorMurgas, Sandra
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorMichel, Martin C.
dc.date.accessioned2023-05-11T11:43:01Z
dc.date.available2023-05-11T11:43:01Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractIntroduction: Pelvic hypoperfusion caused by atherosclerosis has been proposed as a cause of lower urinary tract dysfunction including overactive bladder syndrome (OAB). Limited data indicate that OAB patients with concomitant diabetes or hypertension, known risk factors of atherosclerosis, may exhibit greater baseline OAB symptoms and slightly smaller therapeutic responses to treatment, but the impact of a combined presence of diabetes and hypertension has not been reported. Therefore, we have explored whether the combined presence of both comorbidities is associated with greater baseline OAB symptoms than that of either comorbidity alone. Secondary questions were exploration of the impact of either comorbidity on baseline symptoms, and of the impact of either comorbidity alone and their combination on therapeutic responses. Methods: Data from two non-interventional studies applying treatment with propiverine ER 30 or 45 mg/d for 12 weeks were analyzed. Results: Number of urgency episodes in the combination group was greater than with each comorbidity alone. The impact of comorbidities on baseline intensity of incontinence, frequency or nocturia or Patient Perception of Bladder Condition was less consistent or absent. Either comorbidity alone was associated with a smaller % improvement of symptoms, and their combination had a greater effect than either alone. However, all attenuations associated with comorbidity were small relative to the overall improvement. Conclusions: We conclude that comorbidities of diabetes and hypertension have detectable effects on OAB symptoms and treatment responses, but the small magnitude of these alterations does not justify changing existing paradigms for the clinical management of OAB.
dc.identifier.citationMüderrisoğlu, A. E., Sakul, A. A., Murgas, S., de la Rosette, J. J. M. C. H. ve Michel, M. C. (2023). Association of diabetes, hypertension, and their combination with basal symptoms and treatment responses in overactive bladder patients. Frontiers in Pharmacology, 14. https://dx.doi.org/10.3389/fphar.2023.1144470
dc.identifier.doi10.3389/fphar.2023.1144470
dc.identifier.issn1663-9812
dc.identifier.pmid37063295
dc.identifier.scopus2-s2.0-85153337322
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3389/fphar.2023.1144470
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10938
dc.identifier.volume14
dc.identifier.wos000970641900001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMüderrisoğlu, A. Elif
dc.institutionauthorSakul, Ayse A.
dc.institutionauthorde la Rosette, Jean J. M. C. H.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.relation.ispartofFrontiers in Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectComorbidity
dc.subjectDiabetes
dc.subjectHypertension
dc.subjectNon-Interventional Study
dc.subjectOveractive Bladder Syndrome
dc.subjectPropiverine
dc.subjectTreatment
dc.titleAssociation of diabetes, hypertension, and their combination with basal symptoms and treatment responses in overactive bladder patients
dc.typeArticle

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