The relationship between the use of nucleos(t)ide analogs and metabolic parameters in patients with chronic hepatitis B

Basit Öğe Kaydı
dc.authorid0000-0001-7792-8438
dc.contributor.authorYakut, Aysun
dc.contributor.authorAladağ, Murat
dc.date.accessioned2023-11-13T09:59:45Z
dc.date.available2023-11-13T09:59:45Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractOBJECTIVE: In the treatment of chronic hepatitis-B (CHB), although viral replication load is reduced with the use of nucleos(t)ide analogs, the risk of cirrhosis and hepatocellular carcinoma (HCC) remains. We aimed to investigate the relationship between metabolic syndrome (MetS) and CHB of nucleos(t)ide analogs, which are effective in mortality-morbidity. PATIENTS AND METHODS: In patients who applied to the gastroenterology outpatient clinic between 2021 and 2022, we compared inactive HBsAg-positive patients who did not receive treatment with nucleos(t)ide analogs [entecavir (ETV), lamivudine (LAM), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF)] and medical treatment. Demographic characteristics of the patients were recorded. Lipid profile, Hemoglobin A1c (HbA1c), and HOMA-IR were recorded. The presence of hepatosteatosis was graded ultrasonographically. APRI, Forns Index, and FIB-4 score, which are indicators of non-invasive liver fibrosis, were evaluated. RESULTS: Of the 265 patients, 55.5% (n=147) were males and 44.5% (n=118) were females. The ages of the participants ranged from 18 to 80, with a mean age of 46.54±14.03. It was observed that 62.3% (n=165) of the cases received medical treatment. When the drugs used by those receiving medical treatment were examined, 70.3% (n=116) TDF, 6.1% (n=10) TAF, 3% (n=5) LAM, and 20.6% (n=34) ETV, LDL, HDL, and total cholesterol measurement values of those who received medical treatment were lower, while HOMA-IR values were higher compared to those who did not receive the medical treatment. While the HbA1c value of the patients using ETV was found to be high, the liver stiffness indicator scores of those using TDF were found to be significantly higher. CONCLUSIONS: In this study, in patients with CHB, it has been shown that medical treatment also affects MetS parameters.
dc.identifier.citationYakut, A. ve Aladağ, M. (2023). The relationship between the use of nucleos(t)ide analogs and metabolic parameters in patients with chronic hepatitis B. European Review For Medical and Pharmacological Sciences, 27(19), 9315-9323. https://dx.doi.org/10.26355/eurrev_202310_33959
dc.identifier.doi10.26355/eurrev_202310_33959
dc.identifier.endpage9323
dc.identifier.issn1128-3602
dc.identifier.issn2284-0729
dc.identifier.issue19
dc.identifier.pmid37843345
dc.identifier.scopus2-s2.0-85175585620
dc.identifier.scopusqualityQ2
dc.identifier.startpage9315
dc.identifier.urihttps://dx.doi.org/10.26355/eurrev_202310_33959
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11764
dc.identifier.volume27
dc.identifier.wos001096798300037en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYakut, Aysun
dc.language.isoen
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectChronic Hepatitis B
dc.subjectNucleos(t)ide Analogs
dc.subjectAPRI Score
dc.subjectForns Index
dc.subjectFIB-4 Score
dc.subjectLipid Profile
dc.subjectHOMA-IR
dc.titleThe relationship between the use of nucleos(t)ide analogs and metabolic parameters in patients with chronic hepatitis B
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Yakut-Aysun-2023.pdf
Boyut:
382.75 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu