Pulmonary arterial hemodynamic assessment by a novel ındex in systemic sclerosis patients: Pulmonary pulse transit time

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dc.authorid0000-0002-5794-9730
dc.contributor.authorDoğan, Mehmet
dc.contributor.authorEfe, Tolga Han
dc.contributor.authorÇimen, Tolga
dc.contributor.authorÖzişler, Cem
dc.contributor.authorFelekoğlu, Mehmet Ali
dc.contributor.authorErtem, Ahmet Göktuğ
dc.contributor.authorErat, Mehmet
dc.contributor.authorYi?iner, Ömer
dc.contributor.authorTulmaç, Murat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:46Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:46Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000427629200006
dc.descriptionPubMed ID: 29445936
dc.description.abstractSystemic sclerosis (SSc) is a chronic, inflammatory, and autoimmune connective tissue disease that is associated with vascular lesions, and fibrosis of the skin and visceral organs. Cardiac complications may occur as a secondary effect of SSc as a result of pulmonary arterial hypertension and interstitial lung disease. The objective of this study was to assess whether the pulmonary pulse transit time (pPTT) could serve as a diagnostic marker for pulmonary arterial alterations in patients with SSc, prior to development of pulmonary hypertension. Twenty-five SSc patients as a study group and 25 age- and sex-matched healthy volunteers for the control group were recruited to the study. Right ventricle function parameters, such as tricuspid annular plane systolic excursion (TAPSE), estimated pulmonary artery systolic pressure (ePASP), right ventricular dimensions, right ventricle fractional area changes, and myocardial perfusion index (MPI) were measured and calculated. Pulmonary pulse transit time was defined as the time interval between the R-wave peak in the ECG and the corresponding peak late systolic pulmonary vein flow velocity. Right ventricle myocardial performance index (RVMPI) and eSPAP were significantly higher in the SSc group than the controls (p = 0.032, p = 0.012, respectively). Pulmonary pulse transit time and TAPSE was shorter in the patients with SSc (p = 0.006, p = 0.015, respectively). In correlation analysis, pPTT was inversely correlated with RVMPI (r = - 0.435, p = 0.003), eSPAP (r = - 0.434, p = 0.003), and disease duration (r = - 0.595, p = 0.003). Conversely, it positively correlated with TAPSE (r = 0.345, p = 0.022). pPTT was found to be shorter in SSc patients. pPTT might serve as a surrogate marker of pulmonary hemodynamics in patients with SSc, even prior to the development of pulmonary hypertension.
dc.identifier.citationDoğan, M., Efe, T. H., Çimen, T., Özişler, C., Felekoğlu, M. A., Ertem, A. G. ... Tulmaç, M. (2018). Pulmonary arterial hemodynamic assessment by a novel ındex in systemic sclerosis patients: Pulmonary pulse transit time. Lung, 196(2), 173-178. https://dx.doi.org/10.1007/s00408-018-0098-6
dc.identifier.doi10.1007/s00408-018-0098-6
dc.identifier.endpage178
dc.identifier.issn0341-2040
dc.identifier.issn1432-1750
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage173
dc.identifier.urihttps://dx.doi.org/10.1007/s00408-018-0098-6
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2070
dc.identifier.volume196
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofLungen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectSystemic Sclerosis
dc.subjectPulmonary Pulse Transit Time
dc.subjectPulmonary Hypertension
dc.titlePulmonary arterial hemodynamic assessment by a novel ındex in systemic sclerosis patients: Pulmonary pulse transit time
dc.typeArticle

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