HPTLC quantification, assessment of antioxidant potential and in vivo hypoglycemic activity of Scorzonera latifolia (Fisch. & Mey.) DC and its major compounds

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dc.authorid0000-0002-9354-0000
dc.authorid0000-0002-9971-1122
dc.contributor.authorKırmızı Sönmez, Neriman İpek
dc.contributor.authorBahadır Acıkara, Özlem
dc.contributor.authorŞakul, Ayşe Arzu
dc.contributor.authorBahtiyar, Bade Cevriye
dc.contributor.authorBardakçı, Hilal
dc.contributor.authorBarak, Timur Hakan
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2022-09-12T10:51:47Z
dc.date.available2022-09-12T10:51:47Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalı
dc.description.abstractScorzonera L. (Asteraceae) species have long been the topic of many phytochemical, analytical, and biological studies since various species of the Scorzonera genus have been widely used as food and medicinal purposes. Apart from its traditional use to relieve pain, promote wound healing, treat helminth infections or women infertility, Scorzonera latifolia (Fisch. & Mey.) DC is also used for its antidiabetic activity. We aimed to investigate antidiabetic activity of the aerial parts of the title plant and its major secondary metabolites (hyperoside, isoquercitrin, 7-O-methylisoorientin, isoorientin, swertisin, chlorogenic acid, 4,5-O-dicaffeoylquinic acid and hydrangenol-8-O-?-glucoside) isolated from aerial parts in alloxan-induced diabetic mice. Blood glucose levels were measured four times: before the treatment, after 1st, 2nd, and 4th hours of sample treatments (100 mg/kg i.p.). S. latifolia extract displayed notable decline after 4 hours of administration. Among the metabolites; swertisin, 7-O-methyl-isoorientin, and hydrangenol-8-O-?-glucoside were associated with significant reduction on blood glucose level of alloxan-induced diabetic mice. Due to the strong relationship between oxidative stress and diabetes, antioxidant activity of S. latifolia was additionally tested. Furthermore, 4,5-O-dicaffeoylquinic acid, chlorogenic acid, hyperoside, and swertisin contents as major components of the extract were quantified by HPTLC-densitometry, as their biological effects can be attributed to their phenolic contents.
dc.identifier.citationKırmızı Sönmez, N. İ., Bahadır Acıkara, Ö., Şakul, A. A., Bahtiyar, B. C., Bardakçı, H., Barak, T. H. ... Özbek, H. (2022). HPTLC quantification, assessment of antioxidant potential and in vivo hypoglycemic activity of Scorzonera latifolia (Fisch. & Mey.) DC and its major compounds. South African Journal of Botany, 150, 671-677. http://doi.org/10.1016/j.sajb.2022.07.041
dc.identifier.doi10.1016/j.sajb.2022.07.041
dc.identifier.endpage677
dc.identifier.issn0254-6299
dc.identifier.scopus2-s2.0-85136464821
dc.identifier.scopusqualityQ2
dc.identifier.startpage671
dc.identifier.urihttp://doi.org/10.1016/j.sajb.2022.07.041
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9699
dc.identifier.volume150
dc.identifier.wos000859559700002en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞakul, Ayşe Arzu
dc.institutionauthorBahtiyar, Bade Cevriye
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlloxan
dc.subjectAntidiabetic Activity
dc.subjectScorzonera Latifolia
dc.subjectHPTLC
dc.subjectAntioxidant
dc.subject4,5-O-Dicaffeoylquinic Acid
dc.subjectChlorogenic Acid
dc.subjectHyperoside
dc.subjectSwertisin
dc.titleHPTLC quantification, assessment of antioxidant potential and in vivo hypoglycemic activity of Scorzonera latifolia (Fisch. & Mey.) DC and its major compounds
dc.typeArticle

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