Prevention of tracheal stenosis with pirfenidone after tracheotomy: An experimental study

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dc.authorid0000-0002-1104-563X
dc.contributor.authorTürkmen, Emre
dc.contributor.authorPata, Yavuz Selim
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:35Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000467083900012
dc.descriptionPubMed ID: 30585325
dc.description.abstractObjectives In this study, pirfenidone's role about reducing tracheal stenosis by suppressing fibrosis and inflammation was examined. Methods Tracheotomy was performed on 14 rats, and their cannulas were fixed to tracheotomy area by stoma suture. Two working groups were established. Rats in the first group were given 15 mg/kg/day (1 mL pirfenidone solution) pirfenidone intraperitoneally for 10 days. In the second group as a control group, 1 mL saline solution was applied intraperitoneally. Ten days later, rats were decanulated and kept alive for 3 more weeks. Anesthetized rats were sacrificed on day 30. All rat tracheas were resected between the first and seventh rings. Epithelial damage, inflammation, and fibrosis were determined histopathologically; diameters of intratracheal lumen and their mucosal thickness parameters were determined histomorphometrically; and TGF beta-1 (the growth factor beta), TNF alpha (tumor necrosis factor alpha), and IL-1 beta (Interleukin-1 beta) values were determined immunohistochemically. Results According to the parameters of the control group, fibrosis; diameters of intratracheal lumen; and values of TGF beta-1, TNF alpha, and IL-1 beta were found to be statistically significant. Conclusion In our study, it was found that pirfenidone reduces fibrosis and narrowing of intratracheal lumen diameter significantly. Level of Evidence NA Laryngoscope, 129:E178-E186, 2019
dc.identifier.citationTürkmen, E. ve Pata, Y. S. (2019). Prevention of tracheal stenosis with pirfenidone after tracheotomy: An experimental study. Laryngoscope, 129(5), E178-E186. https://dx.doi.org/10.1002/lary.27704
dc.identifier.doi10.1002/lary.27704
dc.identifier.endpageE186
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue5
dc.identifier.scopusqualityQ1
dc.identifier.startpageE178
dc.identifier.urihttps://dx.doi.org/10.1002/lary.27704
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1661
dc.identifier.volume129
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofLaryngoscopeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectTracheal Stenosis
dc.subjectTracheotomy
dc.subjectPirfenidone
dc.titlePrevention of tracheal stenosis with pirfenidone after tracheotomy: An experimental study
dc.typeArticle

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