The status of spermatogenesis in germ cell tumor bearing testis and its association with metastatic disease

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dc.authorid0000-0003-0906-4417
dc.contributor.authorÇulpan, Meftun
dc.contributor.authorYıldırım, Asıf
dc.contributor.authorÖzkanlı, Sıdıka Şeyma
dc.contributor.authorSobay, Resul
dc.contributor.authorGürsoy, Fatıma
dc.contributor.authorTopaktaş, Ramazan
dc.contributor.authorGümrükçü, Gülistan
dc.contributor.authorGörgel, Sacit Nuri
dc.contributor.authorÇakalağaoğlu, Fulya
dc.contributor.authorÇil, Gökhan
dc.contributor.authorÖzsoy, Şule
dc.contributor.authorGünel, Hümeyra
dc.contributor.authorKüçük, Eyüp Veli
dc.contributor.authorÖztürk, Metin İshak
dc.contributor.authorAkın, Yiğit
dc.contributor.authorMüslümanoğlu, Ahmet Yaser
dc.contributor.authorAydın, Abdullah
dc.contributor.authordel Pilar Laguna Pes, Maria
dc.date.accessioned2024-06-03T07:23:08Z
dc.date.available2024-06-03T07:23:08Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractIntroduction: We aimed to evaluate the status of spermatogenesis detected by histological examination of non-tumoral testicular tissues in tumor bearing testis and its association with advanced stage disease. Patients and Methods: We retrospectively reviewed patients with testicular germ cell tumors (TGCTs) that undergone radical orchiectomy. All non-tumoral areas of the orchiectomy specimens were examined for the status of spermatogenesis. Patients were divided into two groups as localized (stage I) and metastatic (stage II-III) disease and analyzed separately for seminomatous (SGCT) and nonseminomatous germ cell tumors (NSGCT). Results: Four hundred fifty-four patients were included in our final analysis. Of those, 195 patients had SGCT, and 259 patients had NSGCT. Three hundred and six patients had localized disease at the time of diagnosis. Median (Q1-Q3) age was 31 (26 – 38) years and 102 (22.5%) patients had normal spermatogenesis, 177 (39.0%) patients had hypospermatogenesis and 175 (38.5%) patients had no mature spermatozoa. On multivariate logistic regression analysis, embryonal carcinoma >50% (1.944, 95 %CI 1.054-3.585, P = .033) and spermatogenesis status (2.796 95% CI 1.251-6.250, P = .012 for hypospermatogenesis, and 3.907, 95% CI 1.692-9.021, P = .001 for absence of mature spermatozoa) were independently associated with metastatic NSGCT. However, there was not any variables significantly associated with metastatic SGCT on multivariate logistic regression analysis. Conclusion: Our study demonstrated that only 22.5% of patients with TGCTs had normal spermatogenesis in tumor bearing testis. Impaired spermatogenesis (hypospermatogenesis or no mature spermatozoa) and predominant embryonal carcinoma are associated with advanced stage NSGCT.
dc.identifier.citationÇulpan, M., Yıldırım, A., Özkanlı, S. Ş., Sobay, R., Gürsoy, F., Topaktaş, R. ... del Pilar Laguna Pes, M. (2024). The status of spermatogenesis in germ cell tumor bearing testis and its association with metastatic disease. Clinical Genitourinary Cancer, 22(3). http://dx.doi.org/10.1016/j.clgc.2024.102089
dc.identifier.doi10.1016/j.clgc.2024.102089
dc.identifier.issn1558-7673
dc.identifier.issn1938-0682
dc.identifier.issue3
dc.identifier.pmid38728792
dc.identifier.scopus2-s2.0-85192483164
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1016/j.clgc.2024.102089
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12546
dc.identifier.volume22
dc.identifier.wos001240632300001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthordel Pilar Laguna Pes, Maria
dc.language.isoen
dc.relation.ispartofClinical Genitourinary Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMetastasis
dc.subjectNonseminomaatous
dc.subjectOrchiectomy
dc.subjectSeminoma
dc.subjectTesticular Cancer
dc.titleThe status of spermatogenesis in germ cell tumor bearing testis and its association with metastatic disease
dc.typeArticle

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