The prognostic utility of the metastatic lymph node ratio and the number of regional lymph nodes removed from patients with small bowel adenocarcinomas

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dc.contributor.authorAydın, Dinçer
dc.contributor.authorKefeli, Umut
dc.contributor.authorÖzçelik, Melike
dc.contributor.authorErdem, Gökmen Umut
dc.contributor.authorŞendur, Mehmet Ali
dc.contributor.authorYıldırım, Mahmut Emre
dc.contributor.authorÖven, Bala Başak
dc.contributor.authorBilici, Ahmet
dc.contributor.authorGümüş, Mahmut
dc.date.accessioned2023-09-12T07:37:11Z
dc.date.available2023-09-12T07:37:11Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground and Objectives: Small bowel adenocarcinomas (SBAs) are rare tumors of the gastrointestinal system. Lymph node metastasis in patients with curatively resected SBAs is associated with poor prognosis. In this study, we determined the prognostic utility of the number of removed lymph nodes and the metastatic lymph node ratio (the N ratio). Materials and Methods: The data of 97 patients who underwent curative SBA resection in nine hospitals of Turkey were retrospectively evaluated. Univariate and multivariate analyses of potentially prognostic factors including the N ratio and the numbers of regional lymph nodes removed were evaluated. Results: Univariate analysis showed that perineural and vascular invasion, metastatic lymph nodes, advanced TNM stage, and a high N ratio were significant predictors of poor survival. Multivariate analysis revealed that the N ratio was a significant independent predictor of disease-specific survival (DSS). The group with the lowest N ratio exhibited the longest disease-free survival (DFS) and DSS; these decreased significantly as the N ratio increased (both, p < 0.001). There was no significant difference in either DFS or DSS between groups with low and high numbers of dissected lymph nodes (i.e., <13 and =13) (both, p = 0.075). Conclusions: We found that the N ratio was independently prognostic of DSS in patients with radically resected SBAs. The N ratio is a convenient and accurate measure of the severity of lymph node metastasis.
dc.identifier.citationAydın, D., Kefeli, U., Özçelik, M., Erdem, G. U., Şendur, M. A., Yıldırım, M. E. ... Gümüş, M. (2023). The prognostic utility of the metastatic lymph node ratio and the number of regional lymph nodes removed from patients with small bowel adenocarcinomas. Medicina (Lithuania), 59(8). https://dx.doi.org/10.3390/medicina59081472
dc.identifier.doi10.3390/medicina59081472
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue8
dc.identifier.pmid37629761
dc.identifier.scopus2-s2.0-85168716369
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.3390/medicina59081472
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11410
dc.identifier.volume59
dc.identifier.wos001056239200001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBilici, Ahmet
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofMedicina (Lithuania)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectLymph Node Metastasis
dc.subjectMetastatic Lymph Node Ratio
dc.subjectPrognosis
dc.subjectSmall Bowel Adenocarcinoma
dc.titleThe prognostic utility of the metastatic lymph node ratio and the number of regional lymph nodes removed from patients with small bowel adenocarcinomas
dc.typeArticle

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