Neuroprotective potential of carnosine in cerebrovascular diseases
| dc.authorid | 0000-0002-6242-3709 | |
| dc.contributor.author | Neelakandan, A. R. | |
| dc.contributor.author | Bae, Ok-Nam | |
| dc.contributor.author | Majid, Arshad | |
| dc.contributor.author | Çağlayan, Ahmet Burak | |
| dc.contributor.author | Rajanikant, G. K. | |
| dc.date.accessioned | 2021-12-23T06:28:37Z | |
| dc.date.available | 2021-12-23T06:28:37Z | |
| dc.date.issued | 2022 | |
| dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | |
| dc.description.abstract | The growing prevalence, the risk of disabilities, and the lack of effective causal or disease-modifying therapies make cerebrovascular disorders a serious burden. Carnosine, an evolutionarily conserved endogenous dipeptide and over-the-counter food supplement, has a wealth of evidence exhibiting potentially neuroprotective effects. It is a natural, multi-functional, non-toxic anti-glycating antioxidant found in high concentrations in human and mammalian muscle and brain tissues. The physiological presence of carnosine in the brain, ability to cross the blood-brain barrier, and evidence from in vitro, and in vivo studies all point to it as a promising neurotherapeutic agent for cerebrovascular disorders. This review is intended to provide a detailed overview of the neuroprotective role of carnosine in cerebrovascular diseases and summarize existing evidence from cell and animal studies. | |
| dc.identifier.citation | Neelakandan, A. R., Bae, O.-N., Majid, A., Çağlayan, A. B. ve Rajanikant, G. K. (2022). Neuroprotective potential of carnosine in cerebrovascular diseases. International Journal of Peptide Research and Therapeutics, 28(1). https://doi.org/10.1007/s10989-021-10342-5 | |
| dc.identifier.doi | 10.1007/s10989-021-10342-5 | |
| dc.identifier.issn | 1573-3149 | |
| dc.identifier.issn | 1573-3904 | |
| dc.identifier.issue | 1 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.uri | https://doi.org/10.1007/s10989-021-10342-5 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/8714 | |
| dc.identifier.volume | 28 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | Springer | |
| dc.relation.ispartof | International Journal of Peptide Research and Therapeutics | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Carnosine | |
| dc.subject | Ischemic Stroke | |
| dc.subject | Hemorrhagic Stroke | |
| dc.subject | Vascular Dementia | |
| dc.subject | Neuroprotection | |
| dc.title | Neuroprotective potential of carnosine in cerebrovascular diseases | |
| dc.type | Article |
