Ozone (03)-oxygen mixture therapy inhibits endometrial implant growth

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dc.authorid0000-0003-0640-4420
dc.contributor.authorAktün, Lebriz Hale
dc.contributor.authorAcet, Mustafa
dc.contributor.authorAtılgan, Remzi
dc.contributor.authorKaraca, Nilay
dc.contributor.authorYorgunlar, Betül
dc.contributor.authorCan, Behzat
dc.contributor.authorDağlı, Adile Ferda
dc.contributor.authorGül, Hüseyin Fatih
dc.contributor.authorKumbak, Banu
dc.contributor.authorİrban, Arzu
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:35Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000379157300095
dc.description.abstractThe aim of this study was to investigate potential therapeutic efficiency of ozone therapy in the treatment of experimental endometriosis in rats. Fifteen rats were divided into three groups, which were labeled as the (1) sham control, (2) the ozone (treated with intraperitoneal ozone-oxygen mixture) and (3) the GnRH-agonist (given single dose (1 mg) leuprolide acetate depot formulation) group. Endometrial implant activity of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-1 beta (IL-1 beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), and vasculary endothelial growth factor (VEGF) were measured after ozone-therapy. Furthermore, peritoneal fluid activity of SOD, MDA, and TNF-alpha were also measured before and after ozone-therapy. Serum AMH levels of the rats those were given ozone-therapy and control groups were measured. The rats given ozone-therapy showed significantly reduced endometriotic implant volumes. After ozone-therapy, a significant increase in activity of SOD in peritoneal fluid was detected. Conversely, implant levels of SOD in rats given ozone therapy was found to be significantly decreased. Both peritoneal fluid and implant levels of MDA were significantly decreased after ozone-therapy. Implant levels of TNF-alpha, IL-1 beta, and IL-6 were significantly increased following ozone-therapy. VEGF levels of implant was found to be unchanged after ozone-therapy. Serum AMH levels of animals were given ozone-therapy and control groups were similar. The number of both primordial and preantral follicles were significantly decreased after ozone-therapy. However, the number of atretic follicles were similar in ozone-therapy and control groups. Repeated administration of ozone-oxygen therapy in non-toxic doses inhibits growth of endometrial implants.
dc.identifier.citationAktün, L. H., Acet, M., Atılgan, R., Karaca, N., Yorgunlar, B., Can, B. ... İrban, A. (2016). Ozone (03)-oxygen mixture therapy inhibits endometrial implant growth. International Journal of Clinical and Experimental Medicine, 9(6), 11590-11597.
dc.identifier.endpage11597
dc.identifier.issn1940-5901
dc.identifier.issue6
dc.identifier.startpage11590
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2754
dc.identifier.volume9
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherE-Century Publishing Corp
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndometriosis
dc.subjectOzone
dc.subjectOxidative Stress
dc.subjectRat
dc.titleOzone (03)-oxygen mixture therapy inhibits endometrial implant growth
dc.typeArticle

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