Chemopreventive effects of hydatid disease on experimental breast cancer

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dc.authorid0000-0003-0428-2511
dc.contributor.authorAltun, Ahmet
dc.contributor.authorSaraydın, Serpil Ünver
dc.contributor.authorSoylu, Sinan
dc.contributor.authorİnan, Deniz Şahin
dc.contributor.authorYastı, Çınar
dc.contributor.authorÖzdenkaya, Yaşar
dc.contributor.authorKöksal, Binnur
dc.contributor.authorDüger, Cevdet
dc.contributor.authorİşbir, Cemil
dc.contributor.authorTuran, Mustafa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:25Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:25Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractBreast cancer is one of the most common and letal cancers in all over the world. Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches. In this study, we aimed to investigate protective role of hydatid disease against breast cancer. Twenty Wistar rats were divided into two groups of 10 rats each Group I (control) and Group II. In Group II intraperitoneal hydatidosis was performed. Then DMBA was applied to mammary tissues of all rats. Immunohistochemistry studies for Ki-67 and S-100 in the tumoral tissue sections of DMBA induced mammary tumor in rats were performed. TUNEL Assay was used to detect apoptotic cells of tumoral tissue. In vivo anticancer activity testing was carried out by preventing the tumorigenesis by DMBA in mammary tissue of rats. The expressions of the Ki-67 and S-100 protein decreased in rats who had Hydatid Disease (HD) (Group II), compared with the control rats (Group I). TUNEL positive cells were higher in rats with HD (Group II), compared with the control rats (Group I). In vivo studies showed that HD prevented the tumorigenesis by DMBA in mammary tissue of rats with 50 percent.In the light of the evidence the present study showed that HD may have chemopreventive effects on DMBA induced breast cancer.
dc.identifier.citationAltun, A., Saraydın, S. Ü., Soylu, S., İnan, D. Ş., Yastı, Ç., Özdenkaya, Y. ... Turan, M. (2015). Chemopreventive effects of hydatid disease on experimental breast cancer. Asian Pacific Journal of Cancer Prevention, 16(4), 1391-1395. https://dx.doi.org/10.7314/APJCP.2015.16.4.1391
dc.identifier.doi10.7314/APJCP.2015.16.4.1391
dc.identifier.endpage1395
dc.identifier.issn1513-7368
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage1391
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1157
dc.identifier.urihttps://dx.doi.org/10.7314/APJCP.2015.16.4.1391
dc.identifier.volume16
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectBreast Cancer
dc.subjectChemoprevention
dc.subjectHydatid Disease
dc.titleChemopreventive effects of hydatid disease on experimental breast cancer
dc.typeArticle

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