Effective PEGylation method to improve biocompatibility of graphene derivatives

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dc.authorid0000-0002-4634-3864
dc.authorid0000-0003-2776-5807
dc.contributor.authorDemirel, Erhan
dc.contributor.authorKaraca, Ezgi
dc.contributor.authorYüksel Durmaz, Yasemin
dc.date.accessioned2020-01-20T13:03:42Z
dc.date.available2020-01-20T13:03:42Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractThe research on the use of graphene (G) in the biological applications has increased exponentially with emerging concerns regarding its biosafety and potential cytotoxicity. The modification of the surface with biocompatible polymers is a promising approach where poly(ethylene glycol) (PEG) have been extensively used. However, increasing water solubility may not be enough to make G biocompatible since it has different cytotoxicity mechanisms like absorbing cell nutrition on its wide surface area and creating reactive oxygen species through its functional groups. A PEGylation method that uses surface area of graphene oxide (GO) by taking advantage of its solubility in aqueous medium and simultaneously producing reduced GO (rGO) to eliminate the cytotoxicity that comes from functional groups might be a solution to improve biocompatibility and solubility of rGO which is an optimum graphene derivative for biological applications. To have surface PEGylated rGO instead of having edge PEGylated GO; P(PEGMA-co-MMA-co-PMA) copolymers were synthesized and coated on GO via ?-? interactions through multiple pyrene units in the copolymer. Healed conjugated surface of rGO was used as an advantage to increase the efficiency of PEGylation by in-situ reduction of GO to rGO in the presence of copolymer to obtain biocompatible, water dispersible, highly PEGylated rGO.
dc.identifier.citationDemirel, E., Karaca, E. ve Yüksel Durmaz, Y. (2020). Effective PEGylation method to improve biocompatibility of graphene derivatives. European Polymer Journal, 124. http://doi.org/10.1016/j.eurpolymj.2020.109504
dc.identifier.doi10.1016/j.eurpolymj.2020.109504
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2020.109504
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4900
dc.identifier.volume124
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean Polymer Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectGraphene Oxide
dc.subjectReduced Graphene Oxide
dc.subjectPEGylation
dc.subjectCytotoxicity
dc.subjectHemolysis
dc.subjectLDH
dc.subjectMTS
dc.subjectBiocompatibilit
dc.titleEffective PEGylation method to improve biocompatibility of graphene derivatives
dc.typeArticle

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