Preoperative and postoperative high angular resolution diffusion imaging tractography of cerebellar pathways in posterior fossa tumors

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dc.authorid0000-0002-6813-8351
dc.authorid0000-0001-8990-1136
dc.authorid0000-0003-1447-9051
dc.contributor.authorOrtuğ, Alpen
dc.contributor.authorYüzbaşıoğlu, Neslihan
dc.contributor.authorAkalan, Nejat
dc.contributor.authorLevman, Jacob
dc.contributor.authorTakahashi, Emi
dc.date.accessioned2022-12-01T08:48:38Z
dc.date.available2022-12-01T08:48:38Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractThis study aimed to utilize high angular resolution diffusion magnetic resonance imaging (HARDI) tractography in the mapping of the pathways of the cerebellum associated with posterior fossa tumors (infratentorial neoplasms) and to determine whether it is useful for preoperative and postoperative evaluation. Retrospective data from 30 patients (age 2-16 yr) with posterior fossa tumor (17 low grade, 13 high grade) and 30 age-sex-matched healthy controls were used. Structural and diffusion-weighted images were collected at a 3-tesla scanner. Tractography was performed using Diffusion Toolkit software, Q-ball model, FACT algorithm, and angle threshold of 45 degrees. Manually assessed regions of interest were placed to identify reconstructed fiber pathways passing through the superior, medial, and inferior cerebellar peduncles for the preoperative, postoperative, and healthy control groups. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), and track volume measures were obtained and analyzed. Statistically significant differences were found between the preop/postop, preop/control, and postop/control comparisons for the volume of the tracts in both groups. Displacement and disruption of the pathways seemed to differ in relation to the severity of the tumor. The loss of pathways after the operation was associated with selective resection during surgery due to tumor infiltration. There were no FA differences but significantly higher ADC in low-grade tumors, and no difference in both FA and ADC in high-grade tumors. The effects of posterior fossa tumors on cerebellar peduncles and reconstructed pathways were successfully evaluated by HARDI tractography. The technique appears to be useful not only for preoperative but also for postoperative evaluation.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USAen_US
dc.identifier.citationOrtuğ, A., Yüzbaşıoğlu, N., Akalan, N., Levman, J. ve Takahashi, E. (2022). Preoperative and postoperative high angular resolution diffusion imaging tractography of cerebellar pathways in posterior fossa tumors. Clinical Anatomy, 35(8), 1085-1099. https://doi.org/10.1002/ca.23914
dc.identifier.doi10.1002/ca.23914
dc.identifier.endpage1099
dc.identifier.issn0897-3806
dc.identifier.issn1098-2353
dc.identifier.issue8
dc.identifier.pmid35560729
dc.identifier.scopus2-s2.0-85130446727
dc.identifier.scopusqualityQ2
dc.identifier.startpage1085
dc.identifier.urihttps://doi.org/10.1002/ca.23914
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10054
dc.identifier.volume35
dc.identifier.wos000797898500001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOrtuğ, Alpen
dc.institutionauthorYüzbaşıoğlu, Neslihan
dc.institutionauthorAkalan, Nejat
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Anatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCerebellum
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectInfratentorial Neoplasms
dc.titlePreoperative and postoperative high angular resolution diffusion imaging tractography of cerebellar pathways in posterior fossa tumors
dc.typeArticle

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