Nocturnal blood pressure changes in Parkinson's disease: Correlation with autonomic dysfunction and vitamin D levels

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dc.authorid0000-0003-0334-811X
dc.authorid0000-0001-7566-1063
dc.contributor.authorArıcı Düz, Özge
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.date.accessioned2020-09-18T08:20:29Z
dc.date.available2020-09-18T08:20:29Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractNocturnal blood pressure (BP) changes are an indicator of autonomic dysfunction. We aim to investigate the correlation between nocturnal blood pressure (BP) variability, vitamin D levels and Parkinson's disease severity (PD) in this study. Thirty-five patients with PD participated in the study. Disease severity was evaluated by United Parkinson's Disease Rating Scale (UPDRS) and Hoehn and Yahr Scale (HYS). Equivalent levodopa dose was calculated and 25-hydroxyvitamin D levels were measured. The Non-Motor Symptom Questionnaire (NMSQ) was applied to all patients. Ambulatory BP monitoring for 24 h was established. Patients were divided into three groups according to nocturnal BP results: dippers (normal finding-a decline in mean nighttime BP of more than 10%); non-dippers (pathological-a decline in mean nighttime BP of less than 10%); reverse dippers (pathological-an increase in mean nighttime BP) .The mean score of the NMSQ was higher in the group with HYS > 2 (p = 0.050). Four patients were dipper, 17 patients were non-dipper and 16 patients were reverse dipper. There was no significant difference between the three groups in terms of age, gender, disease duration, age of the disease onset, disease stage, disease duration, dopamine agonist usage, levodopa equivalent dose, vitamin D level and NMSQ scores. NMSQ scores are high in advanced PD. Ambulatory BP monitoring is useful in detecting autonomic dysfunction. The number of patients with non-dipping and reverse dipping is high in PD, independent from PD severity, drug dose, vitamin D and the other NMS symptoms.
dc.identifier.citationArıcı Düz, Ö. ve Helvacı Yılmaz, N. (2019). Nocturnal blood pressure changes in Parkinson's disease: Correlation with autonomic dysfunction and vitamin D levels. Acta Neurologica Belgica, 120(4), 915-920. https://dx.doi.org/10.1007/s13760-019-01113-7
dc.identifier.doi10.1007/s13760-019-01113-7
dc.identifier.endpage920
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage915
dc.identifier.urihttps://dx.doi.org/10.1007/s13760-019-01113-7
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5861
dc.identifier.volume120
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAutonomic Dysfunction
dc.subjectParkinson's Disease
dc.subjectNon-Dipper
dc.subjectRevers-Dipper
dc.subjectVitamine D
dc.titleNocturnal blood pressure changes in Parkinson's disease: Correlation with autonomic dysfunction and vitamin D levels
dc.typeArticle

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