Allogeneic hematopoietic stem cell transplantation for adult acute lymphoblastic leukemia: Results from a single center, 1993-2011

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dc.contributor.authorYönal Hindilerden, İpek
dc.contributor.authorKalayoğlu Beşışık, Sevgi F.
dc.contributor.authorGürses-Koç, Nuray
dc.contributor.authorHindilerden, Fehmi
dc.contributor.authorSargın, Deniz
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:35Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:35Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: For adult ALL patients, the indications and appropriate timing of allogeneic hematopoietic stem cell transplantation (AHSCT) continue to be debated. The primary aim of this single-institution study was to compare the results of our adult ALL patients that had been allografted with those reported in the current literature. Subjects and Methods: This study included 53 consecutive adults with acute lymphoblastic leukemia (ALL) who underwent allogeneic hematopoietic stem cell transplantation (AHSCT) with myeloablative (92%) and reduced-intensity (8%) conditioning between 1993 and 2011. Results: Mean patient age was 27 years (SD: 8.62) and donor age was 33.7 years (SD: 9.47). Fourteen patients were in first remission; 21 in ?2nd remission, 15 in relapse and 3 had primary refractory leukemia. Thirty-four, 15 and 4 patients received busulfan plus cyclophosphamide, cyclophosphamide/total body irradiation and fludarabine-based regimens, respectively. For graft-versus-host disease (GVHD) prophylaxis, cyclosporine plus methotrexate were used. Forty-six donors were related and 7 were unrelated. Thirty patients received granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood and 23 received bone marrow as stem cell source. Twenty-six patients relapsed at a mean duration of 11.3 months (SD: 19.1). Forty-four patients succumbed to their disease after a mean follow-up of 13.6 months (SD: 19.5). The cause of mortality was relapse (n=24; 54.5%) and transplant-related etiologies (n=20; 45.5%). The estimated five year probabilities of overall survival (OS) and progression-free survival (PFS) were 37% and 12%, respectively. Conclusion: By multivariate analyses, transplantation in first remission was the most important predictor of transplant success.
dc.identifier.citationYönal-Hindilerden, İ., Kalayoğlu-Beşışık, S. F., Gürses-Koç, N., Hindilerden, F. ve Sargın, D. (2017). Allogeneic hematopoietic stem cell transplantation for adult acute lymphoblastic leukemia: Results from a single center, 1993-2011. International Journal of Hematology-Oncology and Stem Cell Research, 11(1), 58-62.
dc.identifier.endpage62
dc.identifier.issn1735-1243
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage58
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1202
dc.identifier.volume11
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTehran University of Medical Sciences (TUMS)
dc.relation.ispartofInternational Journal of Hematology-Oncology and Stem Cell Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute Lymphoblastic Leukemia
dc.subjectAllogeneic Hematopoietic Stem Cell Transplantation
dc.subjectOverall Survival
dc.subjectProgression-Free Survival
dc.titleAllogeneic hematopoietic stem cell transplantation for adult acute lymphoblastic leukemia: Results from a single center, 1993-2011
dc.typeArticle

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