Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia?

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dc.authorid0000-0002-3691-5216
dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-2306-5937
dc.contributor.authorYuluğ, Burak
dc.contributor.authorAyyıldız, Behçet
dc.contributor.authorAyyıldız, Sevilay
dc.contributor.authorSayman, Dila
dc.contributor.authorSalar, Ali Behram
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorÖzdemir, Ece
dc.contributor.authorÖzşimşek, Ahmet
dc.contributor.authorKurt, Çağla Ceren
dc.contributor.authorLakadamyalı, Hatice
dc.contributor.authorAktürk, Aynur
dc.contributor.authorAltay, Özlem
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorMardinoğlu, Adil
dc.date.accessioned2023-09-29T09:55:45Z
dc.date.available2023-09-29T09:55:45Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractAlthough no longer considered a public health threat, post-COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID-19. Recent studies have also suggested that COVID may be represent a critical risk factor for the development of Alzheimer's disease (AD). We compared 17 COVID patients with 20 controls and evaluated the effects of COVID-19 on general cognitive performance, hippocampal volume, and connections using structural and seed-based connectivity analysis. We showed that COVID patients exhibited considerably worse cognitive functioning and increased hippocampal connectivity supported by the strong correlation between hippocampal connectivity and cognitive scores. Our findings of higher hippocampal connectivity with no observable hippocampal morphological changes even in mild COVID cases may be represent evidence of a prestructural compensatory mechanism for stimulating additional neuronal resources to combat cognitive dysfunction as recently shown for the prodromal stages of degenerative cognitive disorders. Our findings may be also important in light of recent data showing that other viral infections as well as COVID may constitute a critical risk factor for the development of AD. To our knowledge, this is the first study that investigated network differences in COVID patients, with a particular focus on compensatory hippocampal connectivity.
dc.description.sponsorshipResearch Institute for Health and Technologies ; SABITA ; Istanbul Medipol Universityen_US
dc.identifier.citationYuluğ, B., Ayyıldız, B., Ayyıldız, S., Sayman, D., Salar, A. B., Çankaya, Ş. ... Mardinoğlu, A. (2023). Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia? Journal of Medical Virology, 95(9). https://doi.org/10.1002/jmv.29072
dc.identifier.doi10.1002/jmv.29072
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue9
dc.identifier.pmid37724347
dc.identifier.scopus2-s2.0-85171575554
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/jmv.29072
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11505
dc.identifier.volume95
dc.identifier.wos001080804000006en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSalar, Ali Behram
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorVelioğlu, Halil Aziz
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofJournal of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCognition
dc.subjectCOVID Infection
dc.subjectfMRI
dc.subjectHippocampal Connectivity
dc.titleInfection with COVID-19 is no longer a public emergency: But what about degenerative dementia?
dc.typeArticle

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