Fecal microbiota transplantation in autoimmune diseases - an extensive paper on a pathogenetic therapy

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dc.authorid0000-0002-7413-3426
dc.authorid0000-0002-7919-1326
dc.contributor.authorSeida, İsa
dc.contributor.authorAl Shawaf, Maisam
dc.contributor.authorMahroum, Naim
dc.date.accessioned2024-05-13T06:04:50Z
dc.date.available2024-05-13T06:04:50Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractThe role of infections in the pathogenesis of autoimmune diseases has long been recognized and reported. In addition to infectious agents, the internal composition of the "friendly" living bacteria, (microbiome) and its correlation to immune balance and dysregulation have drawn the attention of researchers for decades. Nevertheless, only recently, scientific papers regarding the potential role of transferring microbiome from healthy donor subjects to patients with autoimmune diseases has been proposed. Fecal microbiota transplantation or FMT, carries the logic of transferring microorganisms responsible for immune balance from healthy donors to individuals with immune dysregulation or more accurately for our paper, autoimmune diseases. Viewing the microbiome as a pathogenetic player allows us to consider FMT as a pathogenetic-based treatment. Promising results alongside improved outcomes have been demonstrated in patients with different autoimmune diseases following FMT. Therefore, in our current extensive review, we aimed to highlight the implication of FMT in various autoimmune diseases, such as inflammatory bowel disease, autoimmune thyroid and liver diseases, systemic lupus erythematosus, and type 1 diabetes mellitus, among others. Presenting all the aspects of FMT in more than 12 autoimmune diseases in one paper, to the best of our knowledge, is the first time presented in medical literature. Viewing FMT as such could contribute to better understanding and newer application of the model in the therapy of autoimmune diseases, indeed.
dc.identifier.citationSeida, İ., Al Shawaf, M. ve Mahroum, N. (2024). Fecal microbiota transplantation in autoimmune diseases - an extensive paper on a pathogenetic therapy. Autoimmunity Reviews, 23(7-8). http://dx.doi.org/10.1016/j.autrev.2024.103541
dc.identifier.doi10.1016/j.autrev.2024.103541
dc.identifier.issn1568-9972
dc.identifier.issn1873-0183
dc.identifier.issue45511
dc.identifier.pmid38593970
dc.identifier.scopus2-s2.0-85201408652
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1016/j.autrev.2024.103541
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12444
dc.identifier.volume23
dc.identifier.wos001298994100001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSeida, İsa
dc.institutionauthorAl Shawaf, Maisam
dc.institutionauthorMahroum, Naim
dc.language.isoen
dc.relation.ispartofAutoimmunity Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutoimmunity
dc.subjectFecal Microbiota Transplantation
dc.subjectInfection And Autoimmunity
dc.subjectMicrobiome
dc.titleFecal microbiota transplantation in autoimmune diseases - an extensive paper on a pathogenetic therapy
dc.typeOther

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