Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder

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dc.authorid0000-0003-1980-700X
dc.authorid0000-0002-2306-5937
dc.authorid0000-0001-5118-4776
dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-9704-6173
dc.contributor.authorUykur, Abdullah Burak
dc.contributor.authorYıldız, Sultan
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorÖzşimşek, Ahmet
dc.contributor.authorÖzdemir Öktem, Ece
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorErgün, Tarkan
dc.contributor.authorLakadamyalı, Hatice
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorSaatçi, Özlem
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2021-08-19T07:19:45Z
dc.date.available2021-08-19T07:19:45Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractAim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on multiple levels that goes beyond their conventional effects on neurotransmitters. Method: The study was approved by the Local Ethics Committee of Istanbul Medipol University (10840098-604.01.01-E.65129) and followed the Helsinki Declaration principles. In our study, we have evaluated the effect of six weeks of treatment with antidepressants (escitalopram and duloxetine), and tested the underlying brain functional connectivity through a Graph analysis approach in a well-defined first-episode, drug-naive, and non-comorbid population with MDD. Results: Beyond indicating that there was a significant correlation between the antidepressant response and topological characteristics of the brain, our results suggested that global rather than regional network alterations may be implicated in the antidepressant effect. Conclusion: Despite the small-sample size and non-controlled study design, our study provides important and relevant clinical data regarding the underlying mechanisms of the antidepressants on topological dynamics in the human brain.
dc.identifier.citationUykur, A. B., Yıldız, S., Velioğlu, H. A., Özşimşek, A., Özdemir Öktem, E., Bayraktaroğlu, Z. ... Yuluğ, B. (2021). Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder. Journal of Clinical Neuroscience, 84, 82-90. https://dx.doi.org/10.1016/j.jocn.2020.12.001
dc.identifier.doi10.1016/j.jocn.2020.12.001
dc.identifier.endpage90
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.scopusqualityQ2
dc.identifier.startpage82
dc.identifier.urihttps://dx.doi.org/10.1016/j.jocn.2020.12.001
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7870
dc.identifier.volume84
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMajor Depressive Disorder
dc.subjectGraph Analysis
dc.subjectfMRI
dc.subjectEscitalopram
dc.subjectDuloxetine
dc.titleTopological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder
dc.typeArticle

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