Repetitive transcranial magnetic stimulation improves hippocampal n-acetlaspartate levels and visual memory scores in alzheimer's disease

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dc.authorid0000-0002-2306-5937
dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-0742-1305
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorSayman, Dila
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorErtan Akan, Gülhan
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2024-06-25T12:17:47Z
dc.date.available2024-06-25T12:17:47Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.description.abstractThe latest research into the pathophysiology of Alzheimer's Disease (AD) has included several cognitive deficits related to hippocampal functioning. However, current clinical research fails to consider the full extent of the heterogeneous cognitive spectrum of AD, resulting in a lack of the specific methods required to draw definitive diagnostic and therapeutic conclusions. This also includes in-vivo metabolic measurements for tailoring the diagnostic and therapeutic regimens in humans with AD. Magnetic resonance spectroscopy and repetitive transcranial magnetic stimulation (rTMS) are two novel diagnostic and therapeutic approaches that must be modified to treat AD. In the present study, we aimed to investigate the underlying therapeutic role of rTMS in humans with AD by evaluating the in-vivo hippocampal metabolites before and after rTMS treatment. Based on the data obtained using the fMRI data in our previous study and on the references reported in the literature, in the present study, we decided to use hippocampal NAA data after rTMS stimulation and found a significant increase in NAA levels. To the best of our knowledge, no other study has evaluated the effect of rTMS on hippocampal metabolites in humans with AD.
dc.identifier.citationVelioğlu, H. A., Sayman, D., Hanoğlu, L., Ertan Akan, G., Çankaya, Ş. ve Yuluğ, B. (2024). Repetitive transcranial magnetic stimulation improves hippocampal n-acetlaspartate levels and visual memory scores in alzheimer's disease. Archives of Neuropsychiatry, 61(2), 189-192. http://dx.doi.org/10.29399/npa.28420
dc.identifier.endpage192
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue2
dc.identifier.pmid38868852
dc.identifier.scopus2-s2.0-85196558005
dc.identifier.scopusqualityQ3
dc.identifier.startpage189
dc.identifier.urihttp://dx.doi.org/10.29399/npa.28420
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12647
dc.identifier.volume61
dc.identifier.wos001244741800016en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorVelioğlu, Halil Aziz
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorErtan Akan, Gülhan
dc.language.isoen
dc.relation.ispartofArchives of Neuropsychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAD
dc.subjectMRS
dc.subjectNAA
dc.subjectHippocampus
dc.subjectrTMS
dc.titleRepetitive transcranial magnetic stimulation improves hippocampal n-acetlaspartate levels and visual memory scores in alzheimer's disease
dc.title.alternativeRepetitif transkraniyal manyetik stimülasyon ile alzheimer hastalığında hipokampal n-asetilaspartat düzeyinin ve görsel hafıza skorlarının iyileştirilmesi
dc.typeArticle

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