The relationship between the latency period, infection markers, and oxidant and antioxidant states in women with preterm premature rupture of membranes

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dc.contributor.authorİlhan, Nevin
dc.contributor.authorKumbak Aygün, Banu
dc.contributor.authorGüngör, Hilal
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:05Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:05Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000414028200024
dc.descriptionPubMed ID: 28168638
dc.description.abstractA major cause of perinatal morbidity and mortality has been reported to be preterm premature rupture of membranes (PPROM). Our objective was to evaluate oxidant-antioxidant balance, infection parameters, time interval between rupture of membranes and delivery (latency period), and the relationship among all these parameters. Seventy-five cases with PPROM between 24 and 34 gestational weeks were included in the study. A control group of 41 women who gave birth at term were considered as the control group. The relationship among maternal plasma total oxidative stress (TOS), malondialdehyde (MDA), total antioxidant status (TAS), leukocyte counts, CRP, vitamin C and E levels, gestational week, neonatal birthweight, and latency period was evaluated. In cases with PPROM, rupture occurred at an average of 29.4 gestational weeks and premature babies were born at an average of 31.6 gestational weeks. The mortality rate of babies born to PPROM women was 18.7% (14/75) died at or following birth. In the PPROM group, TOS, MDA, and leukocyte counts were found to be significantly higher compared to the control group (p < 0.001). Besides, a significant negative correlation was detected among the latency period, TOS, CRP, and leukocyte counts (p < 0.05). Appropriate treatment protocols that strengthen antioxidant defense systems and taking into consideration the signs of infection can decrease the incidence of PPROM and/or mortality rates of babies born to PPROM women.
dc.description.sponsorshipDepartment of Scientific Research Projectsen_US
dc.description.sponsorshipThis study was funded by the Department of Scientific Research Projects in our University.en_US
dc.identifier.citationİlhan, N., Kumbak Aygün, B. ve Güngör, H. (2017). The relationship between the latency period, infection markers, and oxidant and antioxidant states in women with preterm premature rupture of membranes. Irish Journal of Medical Science, 186(4), 965-970. https://dx.doi.org/10.1007/s11845-017-1570-7
dc.identifier.doi10.1007/s11845-017-1570-7
dc.identifier.endpage970
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage965
dc.identifier.urihttps://dx.doi.org/10.1007/s11845-017-1570-7
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2895
dc.identifier.volume186
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer London Ltd
dc.relation.ispartofIrish Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPPROM
dc.subjectLatency Period
dc.subjectInflammatory Marker
dc.subjectOxidant and Antioxidant States
dc.titleThe relationship between the latency period, infection markers, and oxidant and antioxidant states in women with preterm premature rupture of membranes
dc.typeArticle

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