The potential role of boron in the modulation of gut microbiota composition: an in vivo pilot study

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dc.contributor.authorŞentürk, Nermin Başak
dc.contributor.authorKasapoğlu, Burcu
dc.contributor.authorŞahin, Eray
dc.contributor.authorÖzcan, Orhan
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorOzansoy, Muzaffer Beyza
dc.contributor.authorŞahin, Fikrettin
dc.date.accessioned2025-10-20T11:43:25Z
dc.date.available2025-10-20T11:43:25Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractBackground/Objectives: The role of the gut microbiome in the development and progression of many diseases has received increased attention in recent years. Boron, a trace mineral found in dietary sources, has attracted interest due to its unique electron depletion and coordination characteristics in chemistry, as well as its potential role in modulating the gut microbiota. This study investigates the effects of inorganic boron derivatives on the gut microbiota of mice. Methods: For three weeks, boric acid (BA), sodium pentaborate pentahydrate (NaB), and sodium perborate tetrahydrate (SPT) were dissolved (200 mg/kg each) in drinking water and administered to wild-type BALB/c mice. The composition of the gut microbiota was analyzed to determine the impact of these treatments. Results: The administration of BA significantly altered the composition of the gut microbiota, resulting in a rise in advantageous species such as Barnesiella and Alistipes. Additionally, there was a decrease in some taxa associated with inflammation and illness, such as Clostridium XIVb and Bilophila. Notable increases in genera like Treponema and Catellicoccus were observed, suggesting the potential of boron compounds to enrich microbial communities with unique metabolic functions. Conclusions: These findings indicate that boron compounds may have the potential to influence gut microbiota composition positively, offering potential prebiotic effects. Further research with additional analyses is necessary to fully understand the interaction between boron and microbiota and to explore the possibility of their use as prebiotic agents in clinical settings.
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK)
dc.identifier.citationŞentürk, N., Kasapoğlu, B., Şahin, E., Özcan, O., Ozansoy, M., Ozansoy, M. B. ... Şahin, F. (2024). The potential role of boron in the modulation of gut microbiota composition: an in vivo pilot study. Pharmaceuticals, 14(10). http://dx.doi.org/10.3390/ph17101334
dc.identifier.doi10.3390/ph17101334
dc.identifier.issn1424-8247
dc.identifier.issue10
dc.identifier.pmid39458975
dc.identifier.scopus2-s2.0-85207637290
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.3390/ph17101334
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13124
dc.identifier.volume17
dc.identifier.wosWOS:001341871300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOzansoy, Mehmet
dc.institutionauthorid0000-0002-1079-8832
dc.language.isoen
dc.relation.ispartofPharmaceuticals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/118C039
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBoron Derivatives
dc.subjectCancer
dc.subjectDiabetes
dc.subjectGut Microbiota
dc.subjectNeurodegenerative Diseases
dc.subjectObesity
dc.titleThe potential role of boron in the modulation of gut microbiota composition: an in vivo pilot study
dc.typeArticle

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