Association of maternal serum Netrin-1 and Netrin-4 levels with placenta accreta spectrum

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dc.authorid0000-0002-4092-7316
dc.contributor.authorKaya, Serdar
dc.contributor.authorTurhan, Uğur
dc.contributor.authorDağ, I.
dc.contributor.authorPolat, İbrahim
dc.date.accessioned2023-07-28T07:42:52Z
dc.date.available2023-07-28T07:42:52Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractOBJECTIVE: This study aimed to evaluate maternal serum Netrin-1 and Netrin-4 levels in pregnancies complicated with placenta accreta spectrum.PATIENTS AND METHODS: This cross-sec-tional study enrolled 49 pregnant women with the diagnosis of placenta accreta spectrum as the study group. Gestational age-matched 30 uncomplicated pregnant women with prior ce-sarean delivery and normal placentation were randomly selected as the control group. Mater-nal serum Netrin-1 and Netrin-4 levels were mea-sured between weeks 34 and 36 of gestation.RESULTS: There was no significant difference between the groups in terms of demographic characteristics. Maternal serum Netrin-1 levels were significantly lower in placenta accreta spec-trum cases compared with those in the control group (p=0.038). There was no significant differ-ence between the groups in terms of maternal se-rum Netrin-4 levels (p>0.05). There was a signif-icant negative correlation between maternal se-rum Netrin-1 levels and the number of prior ce-sarean deliveries (r=-0.313, p=0.005).CONCLUSIONS: The observed decrease in maternal serum Netrin-1 levels in placenta ac-creta spectrum cases associated with increased angiogenesis might be one of the factors in-volved in the pathophysiology of this disease.
dc.identifier.citationKaya, S., Turhan, U., Dağ, I. ve Polat, İ. (2023). Association of maternal serum Netrin-1 and Netrin-4 levels with placenta accreta spectrum. European Review for Medical and Pharmacological Sciences, 27(10), 4594-4600. https://dx.doi.org/10.26355/eurrev_202305_32466
dc.identifier.doi10.26355/eurrev_202305_32466
dc.identifier.endpage4600
dc.identifier.issn1128-3602
dc.identifier.issue10
dc.identifier.pmid37259741
dc.identifier.scopus2-s2.0-85160751314
dc.identifier.scopusqualityQ2
dc.identifier.startpage4594
dc.identifier.urihttps://dx.doi.org/10.26355/eurrev_202305_32466
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11274
dc.identifier.volume27
dc.identifier.wos001021187100031en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaya, Serdar
dc.language.isoen
dc.publisherVerduci Editore s.r.l
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAngiogenesis
dc.subjectNetrin-1
dc.subjectNetrin-4
dc.subjectPlacenta Accreta Spectrum
dc.titleAssociation of maternal serum Netrin-1 and Netrin-4 levels with placenta accreta spectrum
dc.typeArticle

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