Intravitreal aflibercept in treatment-resistant pigment epithelial detachment

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dc.authorid0000-0003-4683-8346
dc.contributor.authorKoçak, İbrahim
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:00Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:00Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000401918500013
dc.descriptionPubMed ID: 27444307
dc.description.abstractThe purpose of the study was to assess the efficacy and safety of transition from ranibizumab to aflibercept intravitreal injections in treatment-resistant retinal pigment epithelial detachment (PED). The data of intravitreal ranibizumab treatment-resistant patients who have been switched to aflibercept treatment were reviewed retrospectively. After three monthly injections, bimonthly regimen was performed. The changes of PED height and radius, and the best-corrected visual acuity (BCVA) were analyzed retrospectively. Mean baseline PED height decreased from 297 +/- 151 to 122 +/- 42 mu m at month 12 (P = 0.0007). Mean baseline PED radius decreased from 2371 +/- 882 to 1859 +/- 779 mu m at month 12 (P = 0.0007). No complete PED resolution occurred in any of the patients at the end of the 12 months. Baseline BCVA improved from 0.63 +/- 0.21 to 0.43 +/- 0.17 logMar at month 12 (P = 0.0049). Mean BCVA gain was 1.4 decimal chart lines (7 letters) at month 12. Switching to aflibercept seems to have promising functional and anatomical outcomes with a reasonable complication rate in treatment-resistant PED.
dc.identifier.citationKoçak, İ. (2017). Intravitreal aflibercept in treatment-resistant pigment epithelial detachment. International Ophthalmology, 37(3), 531-537. https://dx.doi.org/10.1007/s10792-016-0294-4
dc.identifier.doi10.1007/s10792-016-0294-4
dc.identifier.endpage537
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage531
dc.identifier.urihttps://dx.doi.org/10.1007/s10792-016-0294-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2873
dc.identifier.volume37
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAflibercept
dc.subjectPigment Epithelial Detachment
dc.subjectAge-Related Macular Degeneration
dc.subjectVEGF Trap
dc.titleIntravitreal aflibercept in treatment-resistant pigment epithelial detachment
dc.typeArticle

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