Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients

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dc.authorid0000-0001-6639-2797
dc.contributor.authorSeyhan, Ekrem Cengiz
dc.contributor.authorGünlüoğlu, Gülşah
dc.contributor.authorGünlüoğlu, Mehmet Zeki
dc.contributor.authorTural, Seda
dc.contributor.authorSökücü, Sinem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:42Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:42Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göğüs Cerrahisi Ana Bilim Dalı
dc.description.abstractBackground: Hemodialysis (HD) patients are at increased risk of reactivation of latent tuberculosis infection (LTBI) compared with the general population. QuantiFERON-TB Gold (QFT-G) for LTBI detection is more promising than tuberculin skin test (TST) in HD patients. AIM: In our study, we evaluated the value of the TST and QFT-G In-Tube (QFG-IT) test in the development of active tuberculosis (TB), in the HD patients, and in healthy controls. Methods: The study enrolled 95 HD patients and ninety age-matched, healthy controls. The TST and QFG-IT were performed. All the subjects were followed up 5 years for active TB disease. Results: Compared to the healthy controls, a high prevalence of LTBI was found in the HD patients by QFG-IT (41% vs. 25%). However, no significant difference was detected by TST (32% vs. 31%). Four HD patients and one healthy control progressed to active TB disease within the 5-year follow-up. For active TB discovered subjects, QFG-IT was positive in all, but TST was positive in two (one patient and one healthy control). In HD patients; sensitivity, specificity, positive and negative predictive values of QFG-IT, and TST for active TB was 100% and 25%, 62% and 67%, 10%, and 3%, and 100% and 95%, respectively. Receiver operating curve analysis revealed that the results are significantly different (P = 0.04). Conclusion: QFG-IT test is a more useful diagnostic method than TST for detecting those who will progress to active TB in HD patients.
dc.identifier.citationSeyhan, E. C., Günlüoğlu, G., Günlüoğlu, M. Z., Tural, S. ve Sökücü, S. (2016). Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients. Annals of Thoracic Medicine, 11(2), 114-120. https://dx.doi.org/10.4103/1817-1737.180023
dc.identifier.doi10.4103/1817-1737.180023
dc.identifier.endpage120
dc.identifier.issn1817-1737
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage114
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1235
dc.identifier.urihttps://dx.doi.org/10.4103/1817-1737.180023
dc.identifier.volume11
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedknow Publications
dc.relation.ispartofAnnals of Thoracic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectActive Tuberculosis
dc.subjectHealthy Controls
dc.subjectHemodialysis Patients
dc.subjectQuantiFERON-Tuberculosis Gold In-Tube
dc.subjectTuberculin Skin Test
dc.titlePredictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients
dc.typeArticle

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