Coronary calcium score, albuminuria and inflammatory markers in type 2 diabetic patients: Associations and prognostic implications

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dc.contributor.authorDayan, Akın
dc.contributor.authorNarin, Burcu
dc.contributor.authorBiteker, Murat
dc.contributor.authorAksoy, Şükrü
dc.contributor.authorFotbolcu, Hakan
dc.contributor.authorDuman, Dursun
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:50Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:50Z
dc.date.issued2012
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000311026100018
dc.descriptionPubMed ID: 22595190
dc.description.abstractAims: To investigate the relationship of coronary artery calcium (CAC) scores with common carotid artery intima media thickness (CCA-IMT), albuminuria and inflammatory factors in type 2 diabetes. Methods and results: 128 asymptomatic type 2 diabetic patients, with at least one cardiovascular risk factor in addition to diabetes, were included in the study. CAC scores, carotid arteries plaque formation and CCA-IMT were assessed. The patients were followed for a mean period of 36.6 +/- 3.3 months. Linear regression analysis identified the logarithmically transformed (Ln) albuminuria (beta = 0.32, P = 0.007), age (beta = 0.04, P = 0.001) and the uric acid (beta = 0.13, P = 0.04) as independent determinants of the CAC score. During follow-up period, cardiovascular events occurred in 18 out of 46 patients with CAC score >= 100 compared with 5 out of 82 patients with CAC score <100 (log rank, P < 0.0001). Multivariate Cox proportional hazards analysis identified LnCAC score (P < 0.0001), LnAlbuminuria (P = 0.01) and uric acid (P = 0.03) as independent predictors for cardiovascular events. Conclusions: There was a significant relationship between CAC score, albuminuria and inflammation in patients with type 2 diabetes. LnCAC score together with LnAlbuminuria and uric acid were identified as independent predictors of cardiovascular events in these patients.
dc.identifier.citationDayan, A., Narin, B., Biteker, M., Aksoy, Ş., Fotbolcu, H. ve Duman, D. (2012). Coronary calcium score, albuminuria and inflammatory markers in type 2 diabetic patients: Associations and prognostic implications. Diabete Reseach and Clinical Practice, 98(1), 98-103. https://dx.doi.org/10.1016/j.diabres.2012.04.012
dc.identifier.doi10.1016/j.diabres.2012.04.012
dc.identifier.endpage103
dc.identifier.issn0168-8227
dc.identifier.issn1872-8227
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage98
dc.identifier.urihttps://dx.doi.org/10.1016/j.diabres.2012.04.012
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2293
dc.identifier.volume98
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofDiabete Reseach and Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes Mellitus
dc.subjectAlbuminuria
dc.subjectCoronary Calcium score
dc.subjectInflammatory Marker
dc.titleCoronary calcium score, albuminuria and inflammatory markers in type 2 diabetic patients: Associations and prognostic implications
dc.typeArticle

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