Effects of melatonin and 5-methoxytryptophol on synovial inflammation in the zymosan-induced rheumatoid arthritis in rats

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dc.authorid0000-0001-6494-8923
dc.contributor.authorSavtekin, Gökçe
dc.contributor.authorTuzum, Mustafa Şenol
dc.contributor.authorUyanık, Lokman Onur
dc.contributor.authorAyalı, Ayşa
dc.contributor.authorÖğünç Velioğlu, Ayliz
dc.contributor.authorÇetinel, Şule
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorŞehirli, Ahmet Özer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:50Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:50Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study is the investigation of synoviocytes, cytokines and metalloproteinases in the synovial inflammation model which is created by zymosan application to temporomandibular joint (TMJ) and effects of pineal hormones melatonin (MEL) and 5-methoxytryptophol (5-MTX) on these parameters. 200-250 g Wistar albino rats of both sexes were used for modeling arthritis in this study. Arthritis model was created by intraarticularly (i.a.) injecting 2 mg zymosan in 40 ml saline into the left temporamandibular joint of the rats while the sham group was created by only injecting 40 ml saline solution (intraarticulary). MEL and 5-MTX administration was made intraperitoneal before zymosan injection. 6 hours after zymosan or saline administration of MEL and 5-MTX the synovial fluid was collected from the animals and the synovial membrane was collected for histological assessment. The administration of zymosan increased the release of IL-1ß and TNF? and the activity of metalloproteinases (MMM-9) and metalloproteinases-2 (MMP-2) and with this administration values got closer to the sham group. The histological evaluation showed significant increase in the intensity of synoviocytes that arose in the inflammation was found to subside. In conclusion, MEL and 5-MTX reducing inflammation in arthritis suggests these agents might constitute a new therapeutic principle clinically.
dc.description.sponsorshipNear East University Centre of Excellence Research Foundationen_US
dc.identifier.citationSavtekin, G., Tuzum, M. Ş., Uyanık, L. O., Ayalı, A., Öğünç Velioğlu, A., Çetinel, Ş. ... Şehirli, A. Ö. (2016). Effects of melatonin and 5-methoxytryptophol on synovial inflammation in the zymosan-induced rheumatoid arthritis in rats. International Journal of Clinical and Experimental Medicine, 9(4), 7137-7144.
dc.identifier.endpage7144
dc.identifier.issn1940-5901
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage7137
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1268
dc.identifier.volume9
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherE-Century Publishing Corporation
dc.relation.ecinfo:eu-repo/grantAgreement/EC/FP7CE021-2015
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject5-Methoxytriptophol
dc.subjectMelatonin
dc.subjectSynovial Membrane
dc.subjectZymosan
dc.titleEffects of melatonin and 5-methoxytryptophol on synovial inflammation in the zymosan-induced rheumatoid arthritis in rats
dc.typeArticle

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